Related Products of 78573-45-2, Adding some certain compound to certain chemical reactions, such as: 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol,molecular formula is C10H11F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78573-45-2.
A solution of (R) -N- [1- (1-naphthyl) ethyl] -2-nitrobenzenesulfonamide in toluene (83 g pure)92 g of triphenylphosphine,72 g of 3- (3-trifluoromethylphenyl) propanol and 125 mL of toluene were added and stirred. Adjust the solution temperature to 50 ° C,DiisopropylazodicarboxylateA diluted solution obtained by adding 330 mL of toluene to 71 g was dropped. After the dripping end50 mL of toluene was added and stirred at 50 ° C. for 1 hour.After completion of the reaction, 133 g of anhydrous magnesium chloride and 42 mL of toluene were added. After stirring at 50 ° C. for 2 hours, the liquid temperature was cooled to 0 ° C.The reaction solution was filtered to remove insolubles, and then washed with 415 mL of toluene cooled to 0° 415 mL of tap water was added to the filtrate and stirred, and the aqueous layer was removed by liquid separation operation. The same operation was repeated twice, and the obtained organic layer was concentrated under reduced pressure at 55 ° C. to 1165 mL,(R) -N- [1- (1-naphthyl) ethyl] -3- [3- (trifluoromethyl) phenyl]Propane-2-nitrobenzenesulfonamide tolueneA solution was obtained (pure yield 127 g, pure yield 100percent, chemical purity 92percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Iwaki Pharmaceutical Co Ltd; Nagasaki, Atsushi; Fukushima, Koichi; (8 pag.)JP2019/14687; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts