With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, molecular weight is 146.23, as common compound, the synthetic route is as follows.Safety of 1,8-Octanediol
General procedure: A mixture of 1,n-diols 1a-d (1.0 mmol), DHP-hexane 3% (v/v) (1.96 mmol) and aqueous 5 M NaHSO4 (01 mL) was prepared. To 1,10-decanediol 1c and 1,12-dodecanediol 1d, 0.2 mL of DMSO were also added to the mixture at the beginning of the reaction. This mixture was stirred at 40 C for 16 h and then extracted with hexane (3 × 20 mL). The combined organic phases were dried (Na2SO4), filtered and then evaporated under reduced pressure. The residue obtained was chromatographed using silica gel using hexane/EtOAc (8:2) to yield pure Compounds 2a-d.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,629-41-4, 1,8-Octanediol, and friends who are interested can also refer to it.
Reference:
Article; Gonalves, Alessandra Mirtes Marques Neves; De Lima, Aline Brito; Da Silva Barbosa, Maria Cristina; De Camargos, Luiz Fernando; De Oliveira, Jlia Teixeira; De Souza Barbosa, Camila; Villar, Jos Augusto Ferreira Perez; Costa, Andr Carvalho; Da Silva, Isabella Viana Gomes; Silva, Luciana Maria; De Pilla Varotti, Fernando; Dos Santos, Fabio Vieira; Viana, Gustavo Henrique Ribeiro; Marine Drugs; vol. 12; 8; (2014); p. 4361 – 4378;,
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