With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6240-11-5, name is 1-Adamantaneethanol, molecular formula is C12H20O, molecular weight is 180.2866, as common compound, the synthetic route is as follows.Quality Control of 1-Adamantaneethanol
A solution of 1-adamantylethanol (3 g, 16.64 mmol) in methylen chloride (50 mL) and triethylamine (2.8 mL, 19.95 mmol) was stirred for 10 minutes. Then methanesulfonyl chloride (1.55 mL, 20.03 mmol) was added and the resulting reaction mixture was stirred at room temperature for 72 hours. The crude was partitioned between methylen chloride and a solution of sodium hydrogen carbonate (4%). The organic layer was washed with water and brine and the solvent was removed under reduced pressure to give the title compound as a yellow oil (4.1 g, 96%), which was used in the next step without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6240-11-5, 1-Adamantaneethanol, and friends who are interested can also refer to it.
Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/68177; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts