Related Products of 722-92-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. A new synthetic method of this compound is introduced below.
General procedure: To the solution of substituted aniline (7 or 21, 10.0 mmol) in pyridine (1 M) at room temperature, aryl sulfonyl chloride (10,10.5 mmol) was added. The mixture was allowed to stir at room temperature for overnight. After the complete consumption of thesubstituted aniline (monitored by TLC), the reaction mixture wasquenched with water, and the aqueous layer was extracted with dichloromethane. The combined organic layer was washed withaqueous copper sulfate. The organic layer was then dried over sodiumsulfate, filtered, and concentrated under reduced pressure.The obtained residue was purified by silica gel (100e200) columnchromatography using n-hexane: EtOAc as an eluent to get phenylbenzene sulfonamides 11, 22.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.
Reference:
Article; Padala, Anil K.; Wani, Abubakar; Vishwakarma, Ram A.; Kumar, Ajay; Bharate, Sandip B.; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 744 – 755;,
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