As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C11H9BrO
stirring to (6-bromonaphthalen-2-yl)methanol (18.1 g, 76.7 mmol, 1.00 eq.) at 0 CPCC (34.6 g, 92.0 mmol, 1.20 eq.) was added portionwise in DCM (300 mL).The mixture was stirred at room temperature for 16 hours and then filtered.The filtrate was concentrated in vacuo. The crude product was purified by silica gel chromatography (petroleum ether: DCM = 10-70%).6-Bromonaphthalene-2-carbaldehyde (12.8 g, a two-step yield of 68%) was obtained as a white solid.
With the rapid development of chemical substances, we look forward to future research findings about 100751-63-1.
Reference:
Patent; Huazhong University of Science and Technology; Zhu Mingqiang; Wang Yalong; Li Chong; Fan Cheng; (28 pag.)CN108530392; (2018); A;,
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