As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H13NO
The aryl fluoride (2 g, 10.6 mmol) was placed in a 100 ml round-bottomed flask and stirred in 20 ml acetonitrile at room temperature. Potassium carbonate (3.3 g, 23.9 mmol, 2.2 eq) and 1,4-trans- amino-cyclohexanol (1.34 g, 11.6 mmol, 1.1 eq) were added and the mixture was then heated at 90 C overnight. The mixture was cooled to room temperature and then concentrated under vacuum. The crude material was purified by silica gel chromatography using 20 – 40 % ethyl acetate in petroleum ether to elute. The product-containing fractions were combined and concentrated under vacuum to provide 1 g (33 %) of the desired aniline as a yellow oil. (ES, m/z): [M+H]+ 285.0; NMR (300 MHz, DMSO): delta 8.04 (d, J = 9.3 Hz, 1H), 7.42 (d, J = 7.8 Hz, 1H), 7.06 (d, J = 1.8 Hz, 1H), 6.82 – 6.86 (m, 1H), 4.59 (d, J = 4.2 Hz, 1H), 3.39 – 3.49 (m, 2H), 1.78 – 1.94 (m, 4H), 1.18 – 1.32 (m, 4H).
With the rapid development of chemical substances, we look forward to future research findings about 27489-62-9.
Reference:
Patent; MERIAL INC.; LONG, Alan; WILKINSON, Douglas, Edward; (224 pag.)WO2016/118638; (2016); A1;,
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