The origin of a common compound about Tetrahydro-2H-thiopyran-4-ol

According to the analysis of related databases, 29683-23-6, the application of this compound in the production field has become more and more popular.

Synthetic Route of 29683-23-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1 b Synthesis of 4-(4-Bromo-3,5-dimethylphenoxy)tetrahydro-2H-thiopyran To a stirring solution of 4-bromo-3,5-dimethylphenol (710 mg, 3.53 mM), tetrahydro-2H-thiopyran-4-ol (501 mg, 4.24 mM, compound of Step 1 a) and PPh3 (2316 mg, 8.83 mM) in anhydrous DCM (10 ml), DIAD (1785 mg, 8.83 mM) was added under Ar atmosphere. The reaction was warmed at RT and stirred for 16h to 18h. The reaction mixture was then concentrated under reduced pressure to afford the crude product which was purified by column chromatography to afford the title compound 4-(4-bromo-3,5-dimethylphenoxy)tetrahydro-2H-thiopyran (320 mg), and compound used for next step without purification. Yield: 30.1 %.

According to the analysis of related databases, 29683-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; MAHAJAN, Vishal, Ashok; SAWARGAVE, Sangameshwar, Prabhakar; WO2013/128378; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts