Related Products of 2919-23-5 , The common heterocyclic compound, 2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
5-Bromo-6-chloronicotinic acid (CAN 29241-62-1, 2.0 g, 8.46 mmol) was dissolved in DMSO (20.0 mL). Cyclobutanol (793 mg, 857 muL, 11.0 mmol) and potassium hydroxide powder (1.42 g, 25.4 mmol) were added and the mixture was stirred at room temperature overnight. Water (20 mL) was added and the mixture was acidified (under ice-water bath cooling) with 37% HCL in water (pH=2). The suspension was filtered, washed with water and the solid was dried to yield 1.88 g (82%) of the title compound as a white solid; MS (ESI): 270.2 (M-H)-.
The synthetic route of 2919-23-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hebeisen, Paul; Matile, Hugues; Roever, Stephan; Wright, Matthew; Jensen, Sannah Zoffmann; US2012/65212; (2012); A1;,
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