Application of 42142-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42142-52-9, name is 3-(Methylamino)-1-phenylpropan-1-ol, molecular formula is C10H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of N-methy-3-phenyl-3-hydroxy phenylpropylamine (25 g, 0.15 mole) in hexamethylphosphorous triamide and potassium tertiary butoxide (19 g, 0.17 mole) at 50-60C was charged 2-flourotoluene (50 g, 0.45 mole) and the contents of the reaction were heated to 105-110C. The reaction was maintained for 19-20 hours. After the completion of the reaction (checked by TLC) there were charged water (250 ml) followed by toluene (250 ml) and the mixture was stirred for 10-15 minutes. The aqueous and organic layers were separated, then the aqueous layer was extracted with toluene (2×75 ml). Thecombined organic layer was washed with water (3×75 ml) and then subjected to distillation to obtain a thick residue. The residue was dissolved in acetone (150 ml) followed by adding oxalic acid and isopropyl ether (200 ml) and the mixture was stirred for 1-1.5 hours at 0-5C, then the obtained solid was separated by filtration and washing with isopropyl ether (100 ml) resulting in the oxalate of atomoxetine. Yield 62.4% and HPLC purity 95.4%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42142-52-9, 3-(Methylamino)-1-phenylpropan-1-ol.
Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/9884; (2006); A1;,
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