Adding a certain compound to certain chemical reactions, such as: 4084-38-2, 2,3,5,6-Tetrafluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H4F4O, blongs to alcohols-buliding-blocks compound. COA of Formula: C7H4F4O
Add in a 100mL three-necked flask2,3,5,6-tetrafluorobenzyl alcohol 4.5g (25mmol),Pyridine 3g,Hexane 40mL,Slow dropCis-2,2-dimethyl-3-(E/Z-2-chloropropenyl)cyclopropanecarboxylic acid chloride 6g (30mmol),The reaction was carried out for 4 hours at room temperature.The organic phase is sequentially treated with 20 mL of 5% sodium hydroxide solution.Wash with 5% hydrochloric acid solution and saturated sodium chloride solution, dry,After desolvation, a pale yellow viscous liquid is obtained.After column chromatography (petroleum ether / ethyl acetate = 20/1), 9.2 g of pale yellow liquid was obtained.The yield was 95%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4084-38-2, 2,3,5,6-Tetrafluorobenzyl alcohol, and friends who are interested can also refer to it.
Reference:
Patent; Mt. Huang College; Han Bingbing; Zheng Zubiao; (15 pag.)CN109776327; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts