Related Products of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Into a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device, 14.6 g (0.1 mol) of adipic acid, 35.1 g (0.3 mol) of N, N-diethylaminoethanol, (0.2mol) of water, filtered to remove the catalyst (direct reuse), the filtrate transferred to another 250ml of three bottles, vacuum distillation (20ml), the reaction mixture was heated to 150 C, After recovery of the solvent, recovery of excess diethylaminoethanol and recovery of the low boiling point matter, 3.0 g of activated clay was added and stirred for 30 minutes to lower the temperature to 80C or lower.And the filtrate afforded 31.10 g of a di-ethylaminoethyl adipate as a yellow oily liquid in a yield of 90.4%.And then adipic acid bis diethylamino ethanol ester and two times the citric acid mixed with stirring heated to120 C,The citric acid is melted and then cooled and crystallized with stirring to form a salt, thereby obtaining a white powdery solid product of adipic acid bis diethylaminoethanol citrate. Its melting point: 117 C.
According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Suzhou Institute of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Siyuan; Qiu, Yexian; (13 pag.)CN105801441; (2016); A;,
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