In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2807-30-9, name is 2-Propoxyethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Propoxyethanol
General procedure: A mixture of the corresponding 4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-6-aryl-3,4,5,6-tetrahydropyrido[2,3-d]pyrimidine-7(8H)-one (VI) (0.42 mmol), Cs2C03 (0.54 mmol) and the corresponding alcohol (9 ml) was heated a reflux overnight. The resulting solution was cooled down, water (100 mL) was added and the reaction crude was neutralized with 2M HCI. The solid was collected by filtration and washed with water, and EtOEt to afford the corresponding 4-alkoxy-substituted pyrido[2,3- d]pyrimidine (XXVII). 1H N M R (400 MHz, DMSO-d(6): delta 10.51 (s, 1H), 7.58 – 7.47 (m, 2H), 7.37 (t, J = 8.1 Hz, 1H), 6.42 (s, 2H), 4.63 (dd, J = 12.9, 9.2 Hz, 1H), 4.35 – 4.32 (m, 2H), 3.63 (t, J = 4.9 Hz, 2H), 3.35 (t, J = 6.6 Hz, 2H), 2.93 – 2.79 (m, 2H), 1.46 (hex, J = 7.3 Hz, 2H), 0.80 (t, J = 7.4 Hz, 3H).
The synthetic route of 2807-30-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INSTITUT QUIMIC DE SARRIA, CETS FUNDACIO PRIVADA; BORRELL BILBAO, Jose Ignacio; TEIXIDO CLOSA, Jordi; CAMARASA NAVARRO, Marta; PUIG DE LA BELLACASA CAZORLA, Raimon; MARTINEZ DE LA SIERRRA, Miguel Angel; FRANCO CIRERA, Sandra; BADIA CORCOLES, Roger; CLOTET SALA, Bonaventura; ESTE ARAQUE, Jose; WO2015/118110; (2015); A1;,
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