Electric Literature of 426831-32-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.426831-32-5, name is (5-Fluoro-2-methoxyphenyl)methanol, molecular formula is C8H9FO2, molecular weight is 156.1543, as common compound, the synthetic route is as follows.
Neat (5-Fluoro-2-methoxy-phenyl) -methanol (19.587g, 1 equiv. ) was added to neat SOC12 (42.2 mL, 4.6 equiv. ) at-78C under a nitrogen atmosphere and the solution was then allowed to warm to room temperature and stirred until evolution of gas had ceased. An equivalent volume of anhydrous toluene was added to the flask and the solution heated to 60C. On cooling the reaction solution was poured onto ice water. The toluene layer was separated and dried (MgSO4) and the solvent removed under reduced pressure. The crude material was sublimed (60-80C/0. 05 mBarr) to give the title compound as a white solid (13.40 g, 61%).’H NMR (300MHz, CDC13) : S 3.87 (s, 3H), 4.60 (s, 2H), 6.79-7. 20 (m, 3H).;
Statistics shows that 426831-32-5 is playing an increasingly important role. we look forward to future research findings about (5-Fluoro-2-methoxyphenyl)methanol.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/60949; (2005); A2;,
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