In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31775-67-4, name is trans-2-Aminocyclopentanol hydrochloride, the common compound, a new synthetic route is introduced below. COA of Formula: C5H12ClNO
To a solution of 1-(4-bromobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (0.83 g) known from a document (Journal of Medicinal Chemistry, 2007, 50, 5471) in DMF (20 mL) were added (1,2-trans)-2-aminocyclopentanol hydrochloride (0.38 g), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (1.1 g) and triethylamine (0.80 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the precipitate was collected by filtration and dried to give the title compound (1.0 g) as a pale-yellow solid. 1H NMR (300MHz, DMSO-d6) delta 1.37-1.94 (5H, m), 2.00-2.17 (1H, m), 3.88-4.10 (2H, m), 5.77 (2H, s), 5.86 (1H, s), 7.13-7.30 (2H, m), 7.44-7.97 (5H, m), 8.29-8.44 (1H, m), 9.08 (1H, s), 10.03 (1H, d, J = 7.4 Hz).
The synthetic route of 31775-67-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Pharmaceutical Company Limited; SAKAMOTO, Hiroki; SUGIMOTO, Takahiro; EP2821401; (2015); A1;,
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