Application of 1454-84-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1454-84-8, name is 1-Nonadecanol, molecular formula is C19H40O, molecular weight is 284.5203, as common compound, the synthetic route is as follows.
General procedure: Methyl 3-hydroxy-2-naphthoate (1mmol) in DMF was added to allyl bromide (1mmol) in the presence of NaH (55%), and stirred at 60 C for 1 day. The solvent was evaporated in vacuo, and the product was extracted with ether three times. The organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. After the alkaline hydrolysis, thionyl chloride was added to prepare the 2-allyloxy-3-naphthoeic acid chloride. Then, either alkyl alcohol or alkyl amine (1mmol; n = 18, 19) with triethylamine(1mmol) was reacted in THF to produce the S1-OCn or S1-NCn, respectively. The products were purified by silica gel column chromatography with CHCl3 as an eluent. The S1-OCn(S1-NCn) was heated at 160 C for 60 min under vacuum without any solvent, and following column chromatography resulted in the production of S2-OCn (S2-NCn).
Statistics shows that 1454-84-8 is playing an increasingly important role. we look forward to future research findings about 1-Nonadecanol.
Reference:
Article; Kikkawa, Yoshihiro; Ishitsuka, Manami; Omori, Kazuhiro; Kashiwada, Ayumi; Tsuzuki, Seiji; Hiratani, Kazuhisa; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 834 – 842;,
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