In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, the common compound, a new synthetic route is introduced below. Safety of (2-(Trifluoromethyl)phenyl)methanol
(2) To a 250 mL four-neck round bottom flask (mechanically stirred,Thermometer, reflux condenser) was added 2-trifluoromethylbenzyl alcohol (88.1 g, 0.5 mol), Then heated to 10 ° C,A solution of thionyl chloride (71.4 g, 0.6 mol)After the dropwise addition, the temperature was raised to 60 ° C, and the reaction was allowed to proceed.Keep T ? 55 ~ 65 /P ? 0.09 MPa The remaining SOCl2 was distilled off under reduced pressure,And then distillation at 75-80 ° C / -0.09 MPa under reduced pressure to give colorless transparent liquid 2-trifluoromethylbenzyl chloride purity> 99percent yield 95percent.
The synthetic route of 346-06-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jin Kai (Liaoning) Chemical Co., Ltd.; Fu, Limin; Wang, Yongcan; Jia, Tiecheng; Yang, Xiaoge; Wang, Xiuying; Wu, Jingrui; (8 pag.)CN106588673; (2017); A;,
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