Related Products of 144-19-4, Adding some certain compound to certain chemical reactions, such as: 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol,molecular formula is C8H18O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144-19-4.
238. 5g of 2, 2, 4-trimethyl-1, 3-pentanediol was placed (TMPD, 1.631 mol) in a 2-13- neck round-bottom flask. To this was added 205.7g DMC (2.283 mol, 40% excess) and 2.2g zinc stearate. The reaction flask was equipped with a thermocouple temperature probe, magnetic stirbar, and a 1″wide, 10″long vacuum-jacketed, silvered column packed with HastelloyG) B, atop which was placed a variable reflux K-head and condenser. The system was purged by bubbling nitrogen into the reaction mixture for 45 minutes prior to being heated. While under an atmosphere of nitrogen, the mixture was heated slowly to 100- 105C. After 30 minutes of heating, the boiling mixture began to reflux at an overhead temperature of 62-64C. The methanol byproduct/DMC azeotrope (typically a 70/30 wt/wt mixture of methanol/DMC) was removed at a reflux to takeoff ratio of between 3: 1 and 8: 1. After 2 hours of continuous heating, the temperature of the reaction mixture slowly began to rise, reaching 150-155C over the course of the next 15.5 hours as methanol was removed from the system. At this point, 37.9g DMC and 79.2g methanol (75.9% of total expected) had been removed from the reaction. The reaction mixture was then cooled to 60C and a vacuum was slowly introduced in order to remove unreacted DMC and additional methanol by-product. During this time, the temperature of the mixture was slowly increased. After 3 hours, the reaction mixture had been warmed to 90-95C and the system pressure had been reduced to 1.0-2. 0 mmHg. The system pressure was then further reduced to 0.5-1. 0 mmHg and the temperature of the mixture increased to 130C. Unreacted TMPD was preferentially removed from the reaction at an overhead temperature of 80-95C followed by distillation of the carbonate product 4-isopropyl-5, 5-dimethyl-1, 3-dioxan-2-one at an overhead temperature of 95-110C. Several cuts were taken during the distillation and analyzed by GC with the following results; Based on the above results (assuming actual wt. % is approximately equal to GC area %), reaction yield = 73.5%.
According to the analysis of related databases, 144-19-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HUNTSMAN PETROCHEMICAL CORPORATION; WO2003/89424; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts