Related Products of 7287-82-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7287-82-3, name is 1-(2-Methylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.
1-(o-Tolyl)ethanol (513 mg, 3.77 mmol, commercially available from, for example, Alfa Aesar) was dissolved in DCM (5 mL) and stirred at 0 C under N2. PBr3 (0.142 mL, 1.507 mmol) wasadded dropwise and the reaction stirred for 30 mm at 0 C, then allowed to slowly warm to rt. A further portion of PBr3 (0.355 mL, 3.77 mmol) was added dropwise at rt and the reaction stirred for1.5 h. The solution was quenched with sat. aq. sodium bicarbonate (20 mL), the aqueous layer was extracted with DCM (3 x 20 mL) and the combined organic layers were dried over a hydrophobic frit and concentrated to give (+/-)-1-(1-bromoethyl)-2-methylbenzene (670 mg, 2.69 mmol, 71.5 %yield) as a colourless oil.1H NMR (400 MHz, DMSO-d6) O ppm 7.54 – 7.60 (m, 1 H) 7.15 – 7.27 (m, 3 H) 5.62 (q, J=6.8 Hz, 1 H) 2.37 (5, 3 H) 2.03 (d, J=6.8 Hz, 3 H)
According to the analysis of related databases, 7287-82-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
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