In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20017-67-8, name is 3,3-Diphenyl-1-propanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks
Dicyclohexylcarbodiimide (12.6 g, 62.4 mmol) is added portion wise with stirring to a solution of difluroacetic acid (4.0 g, 4.0 mL, 62.4 mmol), 3, [3-DIPHENYL-1-] propanol (14.4 g, 13.8 mL, 68.4 mol) and 4-dimethylaminopyridine (732 mg, 6.2 mmol) in ethyl ether (180 [ML)] at [0-5 C.] The reaction mixture is allowed to warm up to r. t. , and stirred at r. t. overnight. Precipitated urea by-product is filtered off and washed with excesses of ethyl ether. Combined filtrates are removed under vacuum, and the title compound is purified by silica gel flash chromatography (eluent: 5% ethyl ether in hexanes). White crystalline solid (17.3 g, 96%). [HPLC] Rt = 7.2. MS (m/z) : 291 [[M+H] +.]
The synthetic route of 20017-67-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/33449; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts