Reference of 626-18-6 ,Some common heterocyclic compound, 626-18-6, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
1,3-benzene dimethanol (82.5 mg, 0.5971 mmol), compound 14 (191.2 mg, 0.5971 mmol), in dichloromethane (5 mL) solution, EDCl / HCl (228.9 mg, 1.1942 mmol) and DMAP (14.6 mg 0.1194 mmol)) were added , under an argon atmosphere and stirred at room temperature for 1 hour. The solvent was evaporated, and the residue was purified by column chromatography (hexane: ethyl acetate = 4: 1 to 2: 1) to give the title compound 17-1 (112.7 mg, 0.2558 mmol, 42.84%, colorless oil) was Obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,626-18-6, its application will become more common.
Reference:
Patent; THE UNIVERSITY OF TOKYO; TOHOKU UNIVERSITY; OHWADA, TOMOHIKO; NAKAMURA, SHO; JUNG, SEJIN; OTANI, YUKO; SAYAMA, MISA; AOKI, JUNKEN; (80 pag.)JP2016/17036; (2016); A;,
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