The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10602-04-7, name is (4-Ethynylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (4-Ethynylphenyl)methanol
To a solution of (4-ethynylphenyl)methanol 1 (0.52 g, 4 mmol) in DCM (20 mL) was added PBr3 (1.08 g, 4 mmol) at 0 °C under N2, the reaction mixture was stirred at room temperature for 1 hour. After consumption of the starting material (by TLC), diluted with water and extracted with DCM. Combined organic extracts were dried over anhydrous MgSO4 and concentrated under reduced pressure to obtain crude product, which was purified by silica gel column chromatography(EtOAc/Hexane 1: 6) to afford compound 2 (0.3 g, 68percent) as yellow oil. ?H NMR (300 MHz, CDC13) 7.56 (d, J= 8.4 Hz, 2H), 7.37 (d, J= 8.2 Hz, 2H), 4.49 (s, 2H), 4.47 (s, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 10602-04-7.
Reference:
Patent; ABBVIE INC.; MICHAELIDES, Michael; HANSEN, Todd; DAI, Yujia; ZHU, Guidong; FREY, Robin; GONG, Jane; PENNING, Thomas; CURTIN, Michael; MCCLELLAN, William; CLARK, Richard; TORRENT, Maricel; MASTRACCHIO, Anthony; KESICKI, Edward A.; KLUGE, Arthur F.; PATANE, Michael A.; VAN DRIE, John H. Jr.; JI, Zhiqin; LAI, Chunqiu C.; WANG, Ce; (1190 pag.)WO2016/44770; (2016); A1;,
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