Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2566-44-1, name is 2-Cyclopropylethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 2566-44-1
General procedure: Diisopropylamine(0.3ml, 1.8mmol)was added to a solution of cyclopropanol (0.1ml, 1.8mmol) and triphosgene(267mg, 0.9mmol) in dichloromethane which was cooled to 0 and stirred for 1 hour at room temperature. 3-Amino-5-((2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)ethynyl)benzoate(Step 2 of example 8)(100mg, 0.18mmol) and diisopropylethylamine(0.12ml, 0.54mmol) was added to the reaction mixture and stirred for 3 hours at room temperature. Water was added to the reaction mixture and the product was extracted into dichloromethane. The combined organic layers were dried over MgSO 4, filtered, evaporated in vacuum and purified using silica chromatography to afford the intermediate compound methyl3-((2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)ethynyl)-5-((cyclopropoxycarbonyl)amino)benzoate(35mg, 30%). [1627] 1H-NMR (CDCl 3, 400MHz): delta 7.96 (m, 1H), 7.84 (m, 2H), 6.86 (d, 1H), 6.69 (dd, 1H), 7.42-7.31 (m, 4H), 6.86 (d, 1H), 6.72 (dd, 1H), 5.64 (s, 2H), 4.82 (s, 2H), 3.92 (s, 3H), 2.16 (m, 1H), 1.31-1.14 (m, 4H).
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Reference:
Patent; IL DONG PHARMACEUTICAL CO., LTD.; KANG, Jae-Hoon; LEE, Hong-Sub; LEE, Yoon-Suk; JEONG, Jin-Ah; KWON, Sung-Wook; KIM, Jeong-Guen; KIM, Kyung-Sun; SONG, Dong-Keun; PARK, Sun-Young; KIM, Kyeo-Jin; CHOI, Ji-Hye; HWANG, Hey-Min; (170 pag.)WO2018/190643; (2018); A1;,
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