As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol, molecular formula is C7H8BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks
Synthesis of 6-bromo-2-(3,5-dimethylphenyl)quinoline(2-Amino-5-bromophenyl)methanol (22 g, 109 mmol), 3,5-dimethylacetophenone (24.2 g, 163 mmol), RuCl2(PPh3)3 (1.05 g, 1.09 mmol), KOH (11.0 g, 196 mmol) were refluxed in 270 mL of toluene for 18 h.Water was collected from the reaction using a Dean-stark trap.The reaction mixture was allowed to cool to room temperature and filtered through a silica gel plug and eluted with 5percent ethyl acetate in hexanes.The product was further purified by Kugelrohr distillation and crystallization from methanol.
With the rapid development of chemical substances, we look forward to future research findings about 20712-12-3.
Reference:
Patent; Universal Display Corporation; US2012/217868; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts