As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33420-52-9, name is 2,2-Difluoropropan-1-ol, molecular formula is C3H6F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 33420-52-9
To a solution of 2,2-difluoropropan-1-ol (1.30 g) in THF (25 mL) was added 60% sodium hydride (0.64 g) at0C, and the mixture was stirred at the same temperature for 20 min. To the reaction mixture was added methyl 4,6-dichloropyrimidine-5-carboxylate (2.55 g), and the mixture was stirred under an argon atmosphere at 0C for 1 hr. Thereaction mixture was diluted with ethyl acetate, and the organic layer was washed with saturated brine, and dried overanhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gelcolumn chromatography (ethyl acetate/hexane) to give the title compound (2.81 g).1H NMR (300 MHz, DMSO-d6) delta 1.70 (3H, t, J = 19.2 Hz), 3.92 (3H, s), 4.77 (2H, t, J = 12.8 Hz), 8.84 (1H, s).
With the rapid development of chemical substances, we look forward to future research findings about 33420-52-9.
Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; SHIMOKAWA, Kenichiro; KOJIMA, Takuto; SAKAMOTO, Hiroki; FUJIMORI, Ikuo; NAKAMURA, Minoru; YAMADA, Masami; MURAKAMI, Masataka; KAMATA, Makoto; SUZUKI, Shinkichi; (78 pag.)EP3144308; (2017); A1;,
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