Synthetic Route of 10488-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The compound B obtained in Example 1 was dissolved in 200 ml of dichloromethane, was added sodium carbonate (37.2 g, 0.35 mol) the reaction solution was cooled to 0 to 5 ° C, acetyl chloride (23.5 g, 0.30 mol) was added dropwise,I insulation reaction 5h, after adding 200 ml of water, the organic layer was washed with water and then with saturated brine, dried and filtered. The solvent was distilled off under reduced pressure to obtain 53.5 g (0.256 mol) of the crude product of Compound C, the molar yield was 95percent.
According to the analysis of related databases, 10488-69-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Yang, Yong; Qiao, Zhitao; Chen, Anfeng; Zhou, Bingcheng; Liu, Bingxian; Zhou, Junan; Ge, Xu; (10 pag.)CN105566242; (2016); A;,
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