Reference of 5259-98-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below.
To a solution of benzylamine (0.66?mL, 6.03?mmol) and 5-chloropentan-1-ol (0.42?mL, 4.02?mmol) in 5?mL of anhydrous acetonitrile, 555?mg of K2CO3 (4.02?mmol) were added. The mixture was stirred at 80?°C for 48?h and concentrated in vacuo. The residue was dissolved with CH2Cl2, and the organic layer was washed twice with a solution of 10percent NaOH, dried on Na2SO4 and evaporated to give the crude product that was purified by flash chromatography, using CH2Cl2/MeOH/NH4OH 95:5:0.5 as eluting system. 160?mg (20.6percent) of title compound as a yellow oil were obtained. 1H NMR (CDCl3) delta: 7.33-7.26 (m, 5H, CH arom.); 3.78 (s, 2H, NCH2Ph); 3.61 (t, J?=?6.4?Hz, 2H, CH2OH); 2.65 (t, J?=?6.8?Hz, 2H, NCH2); 1.88 (s, 1H, NH); 1.61-1.50 (m, 4H, CH2); 1.47-1.42 (m, 2H, CH2) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5259-98-3, its application will become more common.
Reference:
Article; Dei, Silvia; Romanelli, Maria Novella; Manetti, Dina; Chiaramonte, Niccolo; Coronnello, Marcella; Salerno, Milena; Teodori, Elisabetta; Bioorganic and Medicinal Chemistry; vol. 26; 1; (2018); p. 50 – 64;,
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