Related Products of 455-01-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 455-01-6 as follows.
Example 82 3-(Trifluoromethyl)phenethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (72 mg) was added to toluene/triethylamine = 10/1 (7 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (125 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethylphenethyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (101 mg, yield 76%). 1H-NMR (CDCl3, 400 MHz): 8.42 – 8.49 (1H, m), 8.12 (1H, s), 7.61 (1H, s), 7.42 – 7.59 (6H, m), 7.13 – 7.18 (2H, m), 6.76 (1H, s), 6.66 (1H, d, J = 6.6 Hz), 4.44 (2H, t, J = 6.7 Hz), 4.15 (3H, s), 4.08 (3H, s), 3.07 (2H, t, J = 6.7 Hz) Mass spectrometry value (ESI-MS, m/z): 513 (M++1)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,455-01-6, its application will become more common.
Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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