Adding a certain compound to certain chemical reactions, such as: 186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, blongs to alcohols-buliding-blocks compound. name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
tert-Butyl 3-(2-(2-(2-hydroxyethoxy)- ethoxy)ethoxy)propanoate [Broadpharm, 9380 Waples St., Suite 101, San Diego, CA 92121] (50 mg, 0.180 mmol, 1.00 equiv), N-(((9H-fluoren-9-yl)methoxy)- carbonyl)-O-(tert-butyl)-L-serine (69 mg, 0.180 minol, 1.00 equiv) and DMAP (22 mg, 0.180 rnrnol, 1.00 equiv) were dissolved in CH2C12 (0.9 mL) . Upon dissolution of the reagents (about 5 minutes), EDCIoHC1 (52 mg, 0.270 nirnol, 1.50 equiv) was added in one portion at room temperature, and the reaction mixture was stirred for 17.5 hours, after which it was poured into aqueous 1 N HC1 (3 mL) and EtOAc (15 niL) . The aqueous phase was extracted twice with EtOAc (5 mL), and the combined organic phases were washed with aqueous 1 N HC1 (2 mL), saturated aqueous NaHCO3 (2 mL), and saturated aqueous NaC1 (2 mL), sequentially. The organic phase was dried over Na2504, filtered and concentrated. Flash column chromatography (5i02, 5% MeOH/CH2C12) provided 95.7 mg (83%) of the title compound as a colorless oil. ?H NMR (500 MHz, DMSOd 6) 6 7.76 (d, J = 7.5 Hz, 2H), 7.63 (d, J = 7.5 Hz, 1H), 7.62 (d, J = 7.5 Hz, 1H), 7.40 (t, J = 7.5 Hz, 2H), 7.32 (t, J = 7.5 Hz, 2H), 5.68 (d, J = 8.5 Hz, lH), 4.54 – 4.49 (m, 1H), 4.43 – 4.21 (m, SM), 3.85 (br, iN), 3.74 – 3.57 (m, 13H) , 2.49 (t, J = 6.5 Hz, 2H), 1.44 (s, 9H), 1.16 (s, 9H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, and friends who are interested can also refer to it.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; BEUTLER, Bruce; BOGER, Dale, L.; (334 pag.)WO2018/5812; (2018); A1;,
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