Reference of 756520-66-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To the solution of compound 6 (17 mg, 0.13 mmol), 3-morpholinopropan-1-ol (19 mg, 0.13 mmol) and PPh3 (51 mg, 0.19 mmol) in anhydrous THF (5 mL) was added 33 uL DEAD (0.19 mmol) dropwise. The reaction mixture was stirred at room temperature for 3h. After completion of reaction, the reaction mixture was concentrated and the residue was purified by silica gel column chromatography using DCM: MeOH=60:1 as eluents.
According to the analysis of related databases, 756520-66-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; An, Xiao-De; Liu, Hongyan; Xu, Zhong-Liang; Jin, Yi; Peng, Xia; Yao, Ying-Ming; Geng, Meiyu; Long, Ya-Qiu; Bioorganic and Medicinal Chemistry Letters; vol. 25; 3; (2015); p. 708 – 716;,
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