Application of 4415-73-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4415-73-0, name is 1,1-Cyclobutanedimethanol, molecular formula is C6H12O2, molecular weight is 116.1583, as common compound, the synthetic route is as follows.
Step 2:Oxalyl chloride (61.5 ml_, 708 mmol) is added over 1.5 h to a -80 C (internal temperature; Et20/dry-ice bath is used for cooling) solution of DMSO (50.2 ml_, 708 mmol) in DCM (3.00 L). The reaction mixture is allowed to stir at -80 C for 0.5 h, and then a solution of 4a1 (30.9 g, 266 mmol) in DCM (500 mL) is added over 1 h while maintaining an internal temperature of -80 C. The reaction mixture is stirred for 0.5 h at -80 C, and then TEA (297 mL, 2.13 mol) is added over 1 h while keeping an internal temperature of -80 C. The cooling bath is removed, and the reaction mixture is allowed to warm to 10 C over 4 h. The crude material containing 4a2 is used as such in the next step.
Statistics shows that 4415-73-0 is playing an increasingly important role. we look forward to future research findings about 1,1-Cyclobutanedimethanol.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BROCHU, Christian; GRAND-MAITRE, Chantal; FADER, Lee; KUHN, Cyrille; BERTRAND-LAPERLE, Megan; PESANT, Marc; WO2013/26163; (2013); A1;,
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