Reference of 1875-88-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1875-88-3, name is 2-(4-Chlorophenyl)ethanol, molecular formula is C8H9ClO, molecular weight is 156.61, as common compound, the synthetic route is as follows.
General procedure: To a stirred solution of the Dess-Martin reagent (DMP) (1.5mmol) in CH2Cl2 (10mL) under nitrogen, the alcohol (1.0mmol) was added dropwise. The reaction mixture was stirred for 2h and subsequently quenched with saturated aqueous sodium thiosulfate (20mL). After 15min of stirring the layers were separated, the organic layer was washed with water (50mL) and brine (2×50mL) and the aqueous layer was washed with EtOAc (2×25mL). The combined organic layers were dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The thus obtained semisolid was triturated with 10% EtOAc in hexanes. The solid was removed by filtration. The filtrate was concentrated under reduced pressure to yield the final product.
The chemical industry reduces the impact on the environment during synthesis 1875-88-3, I believe this compound will play a more active role in future production and life.
Reference:
Article; Eleftheriadis, Nikolaos; Poelman, Hessel; Leus, Niek G.J.; Honrath, Birgit; Neochoritis, Constantinos G.; Dolga, Amalia; Doemling, Alexander; Dekker, Frank J.; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 786 – 801;,
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