Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15258-73-8, name is (2,6-Dichlorophenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 15258-73-8
To a solution of H-2 (5.11 g, 20.0 mmol), PPh3 (5.30 g, 20.0 mmol), and 2,6-dichlorobenzylalcohol (3.54 g, 20.0 mmol) in dry THF (100 mL) at 0 C. under Ar is added DEAD (3.15 mL, 20.0 mmol). The reaction mixture is kept at 0 C. for 1.5 h and at rt for 1.5 h. It is concentrated to a residue, that is purified by silica flash chromatography (17:3 hexanes/EtOAc) to give 7.61 g of the title compound: TLC (1 7:3 hexanes/EtOAc) Rf 0.57; 1H NMR (CD3SOCD3, 300 MHz) delta 7.85 (1H), 7.62 (1H), 7.58-7.45 (3H), 5.34 (2H).
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Reference:
Patent; Pharmacia & Upjohn Company; Tanabe Seiyaku Co., Ltd.; US6685617; (2004); B1;,
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