Related Products of 346-06-5 ,Some common heterocyclic compound, 346-06-5, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Adding a metal catalyst (1 mol%) to 10 mL of dried cuvettes,CPA (5 mol%) and activated 4A molecular sieve (100 mg) were sealed with a rubber stopper. Ventilation, replacing the air in the system with nitrogen. Through a syringe into a test tube Dichloromethane (1 mL) was added and stirred at -10 C. After that, the alcohol (1equiv), the diazonium compound (1equiv),1,3,5-triaryl-1,3,5-triazine (0.33 equiv) was dissolved in 1 mL of dichloromethane and slowly added to the reaction solvent with a peristaltic pump at a dropping rate of 1 mL/h.After the end of the dropwise addition, the stirring reaction was continued until the consumption of the diazo compound was completed.Stop the reaction,A small amount of the reaction solution was taken up by a capillary and purified by TLC for chiral HPLC analysis.Final purification by column chromatography (silica gel H, eluent:EA: PE = 1:200 to 1:50) gave the white solid product 5b. The yield was 81% and ee% = 94%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; East China Normal University; Xing Dong; Che Jiuwei; Niu Li; Jia Shikun; Hu Wenhao; (107 pag.)CN109896969; (2019); A;,
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