Reference of 115-20-8, Adding some certain compound to certain chemical reactions, such as: 115-20-8, name is Trichloroethanol,molecular formula is C2H3Cl3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115-20-8.
General procedure: Because activation of a carboxylic acid that is adjacent to a chiral center by use of DCC (or EDC) and DMAP can induce epimerization (loss of chiral purity), the condensation reaction between N-protected chiral amino acids (chiral AAs) and the halogenated alcohols is generally performed using a coupling agent (CA) known to minimize or eliminate epimerization (and thereby maintain chiral purity). Generally, such esters were made by reacting the chiral N-protected amino acid (Compound 11 – ) in a suitable solvent such as DCM or DMF by addition of an excess (e.g. 1 .05-5 eq.) of a tertiary organic base such as TEA, NMM or DIPEA and a slight excess (e.g. 1 .1 -1 .3 eq.) of the coupling agent (e.g. HATU or HBTU). A slight excess (e.g. 1 .05 – 1.5 eq.) of the halogenated alcohol was then added and the reaction was monitored by thin layer chromatograph (TLC) until complete. The product was then worked up as discussed in Example 1 , above. Several N-protected esters of chiral amino acids were prepared using this general procedure as summarized in Table 1 B, below, where yield data is also provided.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115-20-8, Trichloroethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TRUCODE GENE REPAIR, INC.; COULL, James, M.; GILDEA, Brian, D.; (182 pag.)WO2018/175927; (2018); A2;,
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