Related Products of 3637-61-4, Adding some certain compound to certain chemical reactions, such as: 3637-61-4, name is Cyclopentanemethanol,molecular formula is C6H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3637-61-4.
Synthesis of methyl 3-(4-cyclopentylmethyloxyphenyl)Propionate (Intermediate 2) (Step e-1) A solution of cyclopentane-methanol (4.05 ml, Ald) in anhydrous tetrahydrofuran (henceforth abbreviated as “THF”, 40 ml) was added with triethylamine (6.49 ml, WAKO), added dropwise with methanesulfonyl chloride (3.48 ml, WAKO) under ice cooling and stirred for 30 minutes.The reaction mixture was added with water (50 ml) and extracted with diethyl ether (80 ml*2).The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure.A solution obtained beforehand by adding 60% sodium hydride (1.15 g, KANTO) to a solution of Intermediate 1 (4.50 g) in N,N-dimethylformamide (henceforth abbreviated as “DMF”, 35 ml) and stirring the mixture for 15 minutes under ice cooling was added with a solution of the aforementioned residue in DMF (10 ml) under ice cooling.The reaction mixture was stirred for 15 minutes, warmed to room temperature, then stirred for 45 minutes and further stirred at 60 C. for 15 hours.The reaction mixture was added with water (100 ml) and diethyl ether (200 ml) for extraction.The organic layer was washed successively with saturated aqueous sodium hydrogencarbonate, saturated aqueous ammonium chloride and saturated brine and dried, and the solvent was evaporated under reduced pressure.The residue was purified by flash column chromatography (hexane:isopropyl ether=9:1) to obtain the title compound (Intermediate 2, 5.58 g).
According to the analysis of related databases, 3637-61-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shoda, Motoshi; Kuriyama, Hiroshi; US2004/44258; (2004); A1;,
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