In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-(2-(Benzyloxy)ethoxy)ethanol
Sodium hydride (4.08 g, 102 mmol) was added portionwise to an ice bath-cooled solution of 2-(2-(benzy- loxy)ethoxy)ethanol (9.14 mE, 51.0 mmol) in THF (200 mE) over 15 minutes. The reaction was stirred for 1 h after which time tert-butyl 2-bromoacetate (8.97 mE, 61.1 mmol) in THF (50 mE) was added dropwise over 1 h. The reaction was stirred at ice bath temperature for 3 hand quenched with ammonium chloride (50 mE). TBME (250 mE) was added and the organic layer washed with brine (2×200 mE). The organic layer was concentrated onto silica and the crude product was purified by chromatography on silica gel (220g column, 0-50% EtOAc/isohexane) to afford the sub-titlecompound (1.95 g) as a colourless oil. ?H NMR (400 MHz, DMSO-d6) oe 7.43-7.20 (m,5H), 4.50 (s, 2H), 3.99 (s, 2H), 3.66-3.47 (m, 8H), 1.42 (s,9H)
The synthetic route of 2050-25-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Respivert Limited; Topivert Pharma Limited; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; (88 pag.)US2017/291917; (2017); A1;,
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