Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5259-98-3, name is 5-Chloropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 5-Chloropentan-1-ol
General procedure: A solution of phthalimide (14.7 g, 0.1 mol) and 5-chloropentanol (11.25 g, 0.1 mol) or6-chloro-hexanol (12.45 g, 0.1 mol) in anhydrous DMF (100 mL) was heated at 150 °C with vigorousstirring in the presence of finely-powdered anhydrous K2CO3 (13.8 g, 0.1 mol) for 12 h. After cooling,the inorganic materials were filtered off and the solvent was evaporated in vacuo (2 mmHg, 100 °C).The residue was dissolved in 150 mL of ethyl acetate, and after standing overnight at 5 °C, the solutionwas filtered and concentrated in vacuo. The residue was taken up in 80 mL of CHCl3. After extractionwith 60 mL of 5percent aqueous solution of NaHCO3 and 3 60 mL of H2O, the solvent was dried overNa2SO4 and removed in vacuo, giving: 2-(5-Hydroxypentyl)-1H-isoindole-1,3(2H)-dione (5a). A sticky oil (on standing for a prolonged period theviscous oil crystallized giving a solid), yield 70percent (16.32 g); m.p. 41?43 °C; Rf = 0.39 (CHCl3/CH3OH20:1); 1H-NMR (300 MHz, CDCl3): delta= 1.40?1.43 (m, 4H, CH2C), 1.53?1.58 (m, CH2CH2OH), 1.66?1.71(m, 3H, CH2CH2N, OH), 3.61?3.63 (t, J = 6.6 Hz, 2H, CH2N), 3.66?3.68 (t, J = 7.2 Hz, 2H, CH2OH),7.68?7.71 (m, 2H, Harom); 7.81?7.84 (m, 2H, H) ppm.
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Reference:
Article; Guryn, Roman; Staszewski, Marek; Stasiak, Anna; Flores, Daniel McNaught; Fogel, Wies?awa Agnieszka; Leurs, Rob; Walczynski, Krzysztof; Molecules; vol. 23; 2; (2018);,
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