In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2568-33-4, name is 3-Methylbutane-1,3-diol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks
To a 50 mL three-necked flask equipped with a side tower packed column charged with 20 g of molecular sieve (4 A), a condenser, a thermometer and a drying tube, 0.26 g of the iron salen complex obtained in Production Example 1, 1.04 g of isoprene glycol (10 mmol),40 g (400 mmol) of methyl methacrylate and 0.08 g of phenothiazine were charged, the flask was immersed in an oil bath set at 120 C. under atmospheric stirring conditions so that the internal temperature of the flask was 100 to 105 C., The distillate fraction was fully refluxed through molecular sieves and transesterification reaction was carried out for 11 hours while returning to the reaction system. Composition analysis of the obtained reaction solution according to Test Example 1 revealed that isoprene glycol was not detected, isoprene glycol monomethacrylate was 0.1%, and isoprene glycol dimethacrylate was 99.9%. To this reaction solution, unreacted methyl methacrylate was distilled off using a rotary evaporator, 5 g of hexane was added, and the precipitated solid was suction filtered using filter paper (removal of solid matter). 5 g of 10 w / v% nitric acid aqueous solution was added to the obtained filtrate, and washing was carried out by mixing and the aqueous layer was removed by separation (washing with an acidic solution). Saturated sodium bicarbonate water was added to the obtained hexane solution to neutralize until the pH became 7. Hexane was distilled off from the hexane solution obtained by liquid separation to obtain 2.05 g of the objective isoprene glycol dimethacrylate.Composition analysis of the obtained target product according to Test Example 1 revealed that isoprene glycol was not detected, isoprene glycol monomethacrylate was 0.1%, and isoprene glycol dimethacrylate was 99.9%. The results evaluated according to Test Examples 1 to 3 are shown in Table 1.
The synthetic route of 2568-33-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KURARAY COMPANY LIMITED; TAKAHATA, YUSUKE; KAJIYASHIKI, TSUYOSHI; HOSOKI, TOMOYA; (21 pag.)JP2018/104360; (2018); A;,
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