Month: July 2021

Application of 7589-27-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred suspension of pyridinium chlorochromate (6.9 g, 21.4 mmol) in CH2Cl2 (100 ml) was added a solution of 2-(4-fluorophenyl)ethanol (3.0 g, 21.4 mmol) in CH2Cl2 (10 ml). The resulting suspension was stirred for 2 hours at room temperature and was then diluted with ether. The resulting suspension was filtered through a pad of Celite and washed with ether. The solvents were removed under reduced pressure to yield the crude title compound as a green oil (2.6 g, 86%), which was used as such for further reaction.1H NMR (300 MHz, CDCl3, 25 C.): delta=9.75 (s, 1H, CH), 7.19-7.22 (m, 2H, PhH), 7.06 (t, J=8.5 Hz, PhH), 3.68 (s, 2H, CH2) ppm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7589-27-7, 2-(4-Fluorophenyl)ethanol.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D; US2012/46278; (2012); A1;,
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Related Products of 1454-85-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1454-85-9, name is Heptadecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Compound 1 (590mg, 1.0mmol), which was prepared from protoporphyrin IX (PPIX) under acid esterification conditions,17 was dissolved in HBr/acetic acid (25percent, 30mL) under nitrogen atmosphere and the mixture was stirred for 2h. All volatile solvents were evaporated under vacuum to yield dimethyl 3,3?-(7,12-bis(1-bromoethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl)dipropionate (2) as a green colored liquid. The resulting liquid was directly dissolved in dichloromethane (50mL), and 1-tridecanol (2.2mmol, 441mg) and Cs2CO3 (2.2mmol, 304mg) were added to the dichloromethane solution. The reaction mixture was again stirred under nitrogen atmosphere for 2h and filtered. The resulting filtrate was concentrated under the reduced pressure and the residue was purified by preparative TLC on silica gel with CH2Cl2/MeOH (20:1) to give compound 3a (218mg, 23percent yield) as a dark violet crystal. Rf=0.8 (CH2Cl2/MeOH 20:1); 1H NMR (400MHz, CDCl3, TMS) delta 10.63 (s, 1H), 10.61 (s, 1H), 10.11 (s, 1H), 10.08 (s, 1H), 6.09 (m, 2H), 4.41?4.45 (m, 4H), 3.73 (s, 3H), 3.71 (s, 3H), 3.70 (s, 3H), 3.69 (s, 3H), 3.68 (s, 3H) 3.67 (s, 3H), 3.65 (m, 4H), 3.28?3.32 (m, 4H), 2.25?2.27 (d, J=7.0Hz, 6H), 1.09?1.80 (m, 42H), 0.84 (t, J=12.9Hz, 6H); 13C NMR (75MHz, CDCl3, TMS) delta 173.7 (2C; C=O), 140.6, 140.4, 138.4, 138.2, 137.2, 136.8, 136.5 (16C; C pyrrole), 98.8, 98.6, 96.8, 96.1, 73.3 (2C, OCH) 69.6 (2C, OCH2), 51.74 (2C; CO2CH3), 37.0 (2C, CH3CH), 31.9 (2C; CH2COOMe), 30.3, 29.5, 29.3, 26.4, 25.5, (24C; ?CH2?), 22.6 (2C; CH2CH2COO), 21.9, 14.1 (2C, CH3C pyrrole), 11.7ppm (2C; CH3C pyrrole); IR (NaCl disc) 3311, 2924, 2853, 1739, 1435, 1100cm?1; MS (ESI, positive): m/z (percent): 991; HRMS (ESI, positive) m/z Calcd for C62H94N4O6 [M+H]+; 991.7252, found: 991.7252.

According to the analysis of related databases, 1454-85-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tachikawa, Shoji; El-Zaria, Mohamed E.; Inomata, Ryu; Sato, Shinichi; Nakamura, Hiroyuki; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4745 – 4751;,
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Related Products of 558-42-9, Adding some certain compound to certain chemical reactions, such as: 558-42-9, name is 1-Chloro-2-methyl-2-propanol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 558-42-9.

5 g (40.94 mmol) of 4-hydroxybenzaldehyde were initially charged in 50 ml of DMF. 4.45 g (40.94 mmol) of 1-chloro-2-methylpropan-2-ol and 6.08 g (57.32 mmol) of sodium carbonate were added, and the mixture was then stirred at 130° C. overnight. Saturated aqueous sodium bicarbonate solution/ethyl acetate were added to the reaction mixture. The precipitate was filtered off and discarded. The two phases were separated from one another, and the aqueous phase was extracted three times with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and concentrated using a rotary evaporator. The residue was purified by column chromatography on silica gel 60 (mobile phase: cyclohexane/ethyl acetate 5/1?1/2). Yield: 8.6 g (82percent of theory, 76percent pure) LC-MS (Method 4): Rt=1.17 min; MS (ESIpos): m/z=195 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta=9.87 (s, 1H), 7.86 (d, 2H), 7.12 (d, 2H), 4.70 (s, 1H), 3.84 (s, 2H), 1.21 (s, 6H).

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Vakalopoulos, Alexandros; Meibom, Daniel; Nell, Peter; Sussmeier, Frank; Albrecht-Kupper, Barbara; Zimmermann, Katja; Keldenich, Joerg; Schneider, Dirk; Krenz, Ursula; US2013/210795; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 702-98-7, 2-Methyladamantan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C11H18O, blongs to alcohols-buliding-blocks compound. Formula: C11H18O

A reactor made of glass was charged with 110 g of toluene, 50 g of n-undecane, 80 g of 2-methyladamantanol, 4.1 g of methacrylic acid and 0.92 g of p-toluenesulfonic monohydrate. The resulting mixture was heated until the reflux of toluene occurred, followed by reflux for 2 hours while distilling off water, whereby 2-methyleneadamantane was prepared it was then cooled to 0 C. A methacrylate forming reaction was carried out by adding 103.6 g of methacrylic acid and 13.7 g of boron trifluoride ethyl ether to it and stirring the resulting mixture for 2 hours. The reaction mixture was washed with 1275.5 g of a 10% aqueous sodium carbonate solution, followed by washing three times with 160 g of deionized water. Toluene was then distilled off at 70 C. under reduced pressure, whereby 148.8 g of crude 2-methyladamantan-2-yl methacrylate was obtained. The resulting product contained 59.9 wt. % of 2-methyladamantan-2-yl methacrylate and 7.6 wt. % of 2-methyleneadamantane.

The synthetic route of 702-98-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Chemical Corporation; US2008/51597; (2008); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: (2-Bromo-5-methoxyphenyl)methanol

Dissolve (2-bromo-5-methoxy-phenyl) -methanol (5.0 g, 23 mmol) in dry dichloromethane (120 mL) and cool to 0 [C] under nitrogen. Add ethyl vinyl ether (2.5 g, [34 MMOL)] followed by [PYRIDINIUMP-TOLUENESULFONATE (580] mg, 2.3 mmol). Warm to room temperature and stir for 2 hours. Pour reaction into saturated aqueous sodium bicarbonate and extract twice with dichloromethane. Combine organic layers and wash with water and brine. Dry with sodium sulfate, filter and concentrate in vacuo to yield 6.6 g (100%) of title compound as a clear colorless [OIL.’H] NMR [(CDC13)] 8 7.41 (d, J= 8.6 Hz, 1H), 7. 08 (d, [J =] 3.1 Hz, 1H), 6.71 (dd, J= 8.8, 3.1 Hz, 1H), 4. [88] (q, J= 5.3 Hz, 1H), 4.65 (ab, Jab = 13.3 Hz, H), 4.55 (ab, Jab = 13.3 Hz, 1H), 3.8 (s, 3H), 3.71 (m, [1H),] 3.55 (m, [1H),] 1.41 (d, [J=] 5.3 Hz, 3H), 1.23 (t, [J=] 7.0 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 150192-39-5.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/9578; (2004); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1467-84-1

REFERENCE SYNTHETIC EXAMPLE 19 4-{[trans-4-(Hydroxymethyl)cyclohexyl]amino}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide To a solution of 4-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (680 mg, 2.09 mol) obtained in Reference Synthetic Example 7 in N,N-dimethylacetamide (1.1 mL), N,N-diisopropylethylamine (1.1 mL) and (trans-4-aminocyclohexyl)methanol (945 mg, 7.31 mmol) obtained in Reference Synthetic Example 12 were added, and the mixture was stirred at 130C for 3 hours. The reaction mixture was allowed to cool to room temperature, mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=5/1) (v/v)) to obtain the title compound as a white solid (781 mg, yield: 89%).

With the rapid development of chemical substances, we look forward to future research findings about 1467-84-1.

Reference:
Patent; Nissan Chemical Industries, Ltd.; TAKAHASHI, Keiji; WATANABE, Tsuneo; HAYASHI, Keishi; KURIHARA, Kazunori; NAKAMURA, Takanori; YAMAMOTO, Akio; NISHIMURA, Takuya; KAMIYAMA, Toshihiko; HIDAKA, Yuuki; EP2955181; (2015); A1;,
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Reference of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

DIPEA (0.061 mL, 0.348 mmol) and l-chloro-2-methylpropan-2-ol (0.018 mL, 0.174 mmol) were added to (S)-l-(6-methoxy-5-methylpyridin-3-yl)-3-(piperidin-3-ylmethoxy)-4,5,7,8- tetrahydro-lH-oxepino[4,5-c]pyrazole (48 mg, 0.116 mmol) in EtOH (1 mL). The reaction mixture was heated to 90 °C for 1 h in a microwave. l-Chloro-2-methylpropan-2-ol (0.018 mL, 0.174 mmol) was added to the reaction mixture which was heated in a microwave for a further 2 h at 90 °C. 1-Chloro- 2-methylpropan-2-ol (0.018 mL, 0.174 mmol) was added to the reaction mixture which was heated in a microwave for a further 5 h. The reaction mixture was concentrated under a stream of nitrogen and purified using MDAP (Method A) to give the title compound (44.5 mg, 86percent). LCMS (Method C) : Rt = 1.31 min, MH+ = 445. 1H NMR (400 MHz, CDCb) delta ppm 7.92 (d, 2=2 Hz, 1H), 7.46 – 7.40 (m, 1H), 4.17 (dd, J=10, 3 Hz, 1H), 4.06 (dd, J=10, 6 Hz, 1H), 3.98 (s, 3H), 3.85 (t, J=5 Hz, 2H), 3.79 (t, J=5 Hz, 2H), 3.70-3.19 (m, 2H), 2.91 – 2.71 (m, 4H), 2.72-2.44 (m, 5H), 2.22 (s, 3H), 1.97 – 1.76 (m, 3H), 1.41 – 1.20 (m, 7H)

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BAXTER, Andrew; BERTRAND, Sophie Marie; CAMPBELL, Matthew; DOWN, Kenneth David; HAFFNER, Curt Dale; HAMBLIN, Julie Nicole; HENLEY, Zoe Alicia; MILLER, William Henry; TALBOT, Eric Philippe Andre; TAYLOR, Jonathan Andrew; (325 pag.)WO2018/192864; (2018); A1;,
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Application of 100-37-8, Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol,molecular formula is C6H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8.

(2R,6S)-tert-Butyl 4-(7-bromo-6-chloro-2-(2-(diethylamino)ethoxy)-8-fluoroquinazolin-4-yl)-2,6-dimethylpiperazine-1-carboxylate To a stirred solution of 2-(diethylamino)ethanol (276 mg, 2.36 mmol) in DMF (20 mL) at RT, NaH (94 mg, 2.36 mmol) was added and the resulting mixture was stirred for 30 min. (2R,6S)-tert-butyl 4-(7-bromo-2,6-dichloro-8-fluoroquinazolin-4-yl)-2,6-dimethylpiperazine-1-carboxylate (600 mg, 1.18 mmol) was added to the reaction mixture and stirred at RT for 2 h. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (MeOH/dichloromethane=40:1) to afford the desired product (140 mg, 20% yield) as a solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-37-8, 2-(Diethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Araxes Pharma LLC; Liu, Yi; Li, Liansheng; Ren, Pingda; (176 pag.)US2018/15087; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1355338-16-7, name is 2-(4-Amino-3-fluorophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H6F7NO, molecular weight is 277.14, as common compound, the synthetic route is as follows.HPLC of Formula: C9H6F7NO

Intermediate 14: tert-Butyl 1-{[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]carbamoyl}-5-(methylsulfonyl)-1,3-dihydro-2H-isoindole-2-carboxylate (0646) (0647) 2-(tert-Butoxycarbonyl)-5-(methylsulfonyl)isoindoline-1-carboxylic acid (345 mg, 1.01 mmol) was suspended in DCM (5 mL) and to this 2-(4-amino-3-fluorophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (280 mg, 1.01 mmol) and triethylamine (0.282 mL, 2.02 mmol) was added. To the resulting solution T3P (1.203 mL, 2.02 mmol) 50% in EtOAc was then added. The reaction was stirred at rt for 30 mins. LCMS indicated complete conversion to product. The reaction was diluted with DCM and washed with 0.5M HCl. The layers were separated using a phase separator and concentrated in vacuo. The residue was purified on silica eluting with 40% EtOAc in heptane. Completely pure fractions were combined and concentrated in vacuo to afford tert-butyl 1-((2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)carbamoyl)-5-(methylsulfonyl)isoindoline-2-carboxylate (402 mg, 66.3%) as a solid. (0648) LC/MS: m/z=601 [M+H]+. 1H NMR (500 MHz, DMSO-d6, mixture of rotamers, 2*:1) delta 1.38*, 1.47 (s, 9H), 3.21, 3.23*(s, 3H), 4.7-4.85 (m, 2H), 5.81*, 5.85 (s, 1H), 7.42-7.58 (m, 2H), 7.67*, 7.72 (d, 1H), 7.88-8.06 (m, 3H), 8.92 (s, 1H), 10.60, 10.63*(s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1355338-16-7, 2-(4-Amino-3-fluorophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; AstraZeneca AB; NARJES, Frank; OLSSON, Roine Ingemar; VON BERG, Stefan; LEVER, Sarah; (112 pag.)US2017/166527; (2017); A1;,
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