Month: June 2021

Adding a certain compound to certain chemical reactions, such as: 15484-46-5, Methyl 2-(hydroxymethyl)acrylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 15484-46-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 15484-46-5

Trifluoromethanesulfonic anhydride (25.0 g) and dichloromethane (80.0 ml) were put into a reaction vessel and cooled to 0 C. Compound (T-8) (10.3 g) and a dichloromethane (160 ml) solution containing trimethylamine (8.97 g) were slowly added dropwise thereto. The obtained solution was poured into 1,6-hexanediol (314 g) and the mixture was stirred at room temperature for 12 hours. The reaction mixture was poured into water, and an aqueous layer was extracted with dichloromethane. The obtained organic layer was washed with water and dried with anhydrous magnesium sulfate. This solution was concentrated under a reduced pressure, and the residue was purified through silica gel chromatography (volume ratio, heptane:ethyl acetate=3:2), and thereby Compound (T-9) (11.3 g; 59%) was obtained.

The synthetic route of 15484-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JNC CORPORATION; JNC PETROCHEMICAL CORPORATION; TANAKA, Hiroyuki; (95 pag.)US2019/390115; (2019); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1875-88-3, name is 2-(4-Chlorophenyl)ethanol, molecular formula is C8H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C8H9ClO

Add 2-thiophene methanol (1 mmol) and toluene (2 mL) to a 10 mL reaction tube.The catalyst CoxMnyO4 (x/y=8) was added, and the reaction mixture was reacted at 60 C for 6 h.After the completion of the reaction, the target product is isolated by column chromatography to obtain the target product V.The yield was 99.9%.

With the rapid development of chemical substances, we look forward to future research findings about 1875-88-3.

Reference:
Patent; Anhui University of Technology; Ke Qingping; Li Dandan; Cui Ping; Xie Ruilun; Liu Xiangchun; Zhao Zhigang; Ling Qiang; (7 pag.)CN108147936; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 329218-12-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 329218-12-4

Step 2:260 g (crude product of several batches, about 1.05 mol) of (3-bromo-4-chlorophenyl)methanol were dissolved in 2.86 litres of dichloromethane, the mixture was cooled to -5 C. and 127.1 g (44.6 ml, 459.6 mmol) of phosphorus tribromide were added slowly. After the addition had ended, the mixture was stirred at -5 C. for another 1 h and then diluted with dichloromethane and water. The organic phase was separated off, dried over magnesium sulphate and concentrated under reduced pressure. This gave, as a crude product, 280.5 g (about 84% of theory) of 2-bromo-4-(bromomethyl)-1-chlorobenzene.GC-MS (Method 1): Rt=5.36 min; m/z=281/283/285 (M+H)+.1H-NMR (400 MHz, DMSO-d6): delta [ppm]=4.71 (s, 2H), 7.49 (dd, 1H), 7.63 (d, 1H), 7.89 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,329218-12-4, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; US2012/172448; (2012); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 19819-98-8 , The common heterocyclic compound, 19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 5 2-Methylphenethyl sulfamate A mixture of 2.65 g (0.019 mole) of 2-methylphenethyl alcohol in 10 ml DMF was added dropwise to a suspension of sodium hydride (1.1 g, 60% in oil; 0.08 mole) in 35 ml DMF at 0-5 C. The suspension was stirred for 20 min under argon after which sulfamoyl chloride (2.86 g, 0.02 mole) was added portion wise at 0-5 C. After stirring for 20 min the resultant suspension was poured into ice and extracted twice with Et2 O. The combined organic phases were washed with saturated brine, dried over potassium carbonate and concentrated in vacuo to a syrup which was purified by preparative HPLC with hexane/EtOAc (1:1, v/v) as the eluant to give 1.76 g (43%) of the title compound as a solid, mp 50-52 C. Elemental Analysis: Calculated for C9 H13 NO3 S: C, 50.22; H, 6.09; N, 6.51. Found: C, 50.40; H, 6.14; N, 6.43.

The synthetic route of 19819-98-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; McNeilab, Inc.; US4792569; (1988); A;,
Alcohol – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol). A new synthetic method of this compound is introduced below., Quality Control of 2,2′-Oxybis(ethan-1-ol)

General procedure: Dioxane (15 mL), alkyl halide (25 mmol), and tetrabutylammonium bromide (0.4 g, 1.2 mmol) were added to a solution of KOH (1.6 g, 27.5 mmol) in glycol (75-125 mmol). After stirring at 100-105 C for 5-10 h, the reaction mixture was diluted with CHCl3 (15 mL) and water (10 mL). The organic layer was separated, washed with water (3×20 mL), dried with Na2SO4, and evaporated in vacuo, and the residue was distilled using Vigreux column. For each particular case, the ratio of the starting reagents, yields, physicochemical parameters, and 1H NMR spectral data for monoalkyl ethers 8a-e are givenin Table 6.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 111-46-6, 2,2′-Oxybis(ethan-1-ol).

Reference:
Article; Kharlamov; Artyushin; Bondarenko; Russian Chemical Bulletin; vol. 63; 11; (2014); p. 2445 – 2454; Izv. Akad. Nauk, Ser. Khim.; 11; (2014); p. 2445 – 2454;,
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Adding a certain compound to certain chemical reactions, such as: 13826-35-2, (3-Phenoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13826-35-2, blongs to alcohols-buliding-blocks compound. Recommanded Product: 13826-35-2

General procedure: 4-Phenylphenol 2 (34.0mg, 0.2mmol) and cesium carbonate (97.7mg, 0.3mmol) were weighed to a sealed Schlenk (25mL) under Ar atmosphere. Pentafluorobenzene 1a (50.4mg, 0.3mmol) and DMSO (2.0mL) were added to the sealed Schlenk via syringe at room temperature respectively. The mixture was stirred at room temperature until the completion of the reaction (by TLC). Water (5mL) was added and the mixture was extracted with ethyl acetate (3×10mL). The organic extracts were combined, dried with anhydrous magnesium sulfate and then concentrated in vacuo. The residue was purified on silica gel to afford the product 3o (54.1mg, 85% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13826-35-2, its application will become more common.

Reference:
Article; Liu, Cuibo; Cao, Liming; Yin, Xuguang; Xu, Haolan; Zhang, Bin; Journal of Fluorine Chemistry; vol. 156; (2013); p. 51 – 60;,
Alcohol – Wikipedia,
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Reference of 24034-73-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol, molecular formula is C20H34O, molecular weight is 290.4834, as common compound, the synthetic route is as follows.

[0270] The resulting 2E-conjugated ester 8 was reduced to the corresponding 2E-alcohol 9 by means of a lithium aluminum hydride (LAH) treatment, which was then converted into the corresponding 2E,6E, 10E-geranylgeranyl bromide 10 by means of phosphorus tribromide (PBr3) treatment in ethyl ether (EE) or with Ph3P and CBr in acetonitrile (ACN) at 0C. Furthermore, the interaction of carbanion (derived from ethyl acetoacetate 5 and sodium ethoxide) with the bromide 10 at 0C afforded the desired 2E,6E,10E-geranylgeranyl ketoester 11, a precursor needed for 5E,9E,13E-geranylgeranyl acetone 1. The subsequent ester hydrolysis and decarboxylation of ketoester 11 using aq. 5N KOH at 80C yielded the requisite 5E,9E,13E-geranylgeranyl acetone 1. TLC Rf: 0.28 (5% Ethyl Acetate in Hexanes); LC Retention time: 16.68 min; MS (m/e): 313 [M – 18 + H]+, 331 [MH]+, 353 [M + K]. Example 2: S-Z.SE.IBE-Geranylgeranyl Acetone Synthesis Scheme 2

The chemical industry reduces the impact on the environment during synthesis 24034-73-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68208-26-4, name is 3-Amino-3-(4-chlorophenyl)-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 68208-26-4

Intermediate 30: tert-butyl l-(4-chlorophenyl)-3-hvdroxypropylcarbamateDi-tert-butyl dicarbonate (0.705 g, 3.23 mmol) was added to 3-amino-3-(4- chlorophenyl)propan-l-ol (Intermediate 29) (0.500 g, 2.69 mmol) in DCM (30 mL) at 220C. The resulting solution was stirred at 22 0C for 2 hours. The mixture was concentrated and the residue was purified by flash silica chromatography, elution gradient 0 to 4% (10:1 MeOH/conc. NH3 (aq)) in DCM. Pure fractions were evaporated to dryness to afford tert-butyl l-(4-chlorophenyl)-3-hydroxypropylcarbamate (0.759 g, 99 %) as a white solid.IH NMR (399.902 MHz, CDC13) delta 1.43 (9H, s), 1.81 (IH, m), 2.04 (IH, m), 2.74 (IH, br.s), 3.69 (2H, m), 4.88 (IH, br.s), 5.04 (IH, d), 7.23 (2H, d), 7.32 (2H, d). MS m/e MH” 284, 286

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 68208-26-4, 3-Amino-3-(4-chlorophenyl)-1-propanol.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/47563; (2009); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 2568-33-4, 3-Methylbutane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 2568-33-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 2568-33-4

General procedure: In the Schlenk reaction vessel,Methyltri n-octylphosphonium methyl carbonate([Me (n-octyl) 3P] + [OCO2Me]-,Charge the catalyst (C1a), 55.8 muL, 0.12 mmol),Methyl methacrylate (MMA, 4 mL) was added and stirred at room temperature for 1 to 2 minutes. Then, 3-methylbutane-1,3-diol (compound (3a), 21 3 muL, 2.0 mmol), internal standard substance (4,4′-di-tert-butylbiphenyl, 53.3 mg, 0.20 mmol), 1.0 g of dried powdery molecular sieves 5A (MS 5A) was added, and the mixture was stirred at room temperature (25 C.) for 3 hours to carry out an ester exchange reaction represented by the following formula. During the reaction, the progress of the reaction was confirmed by thin layer chromatography (TLC) as appropriate. The reaction mixture was passed through a celite pad to remove MS 5A, MMA was distilled off from the mixture under reduced pressure, and after concentration, the yield of the reaction product was measured by 1H NMR (internal standard method). The concentrate was subjected to silica gel column chromatography (n-hexane: ethyl acetate = 50: 1 to 10: 1) to isolate a carboxylic acid monoester (compound (4a)). The yield and yield of the reaction product are shown in Table 1. In the reaction system, the reaction between the catalyst (C1a) and the alcohol derived from the raw material (compound (3a)) causes Me (n-octyl) 3P] + [OR5]-as a catalytically active species.(Most R5 is 3-hydroxy-3-methylbutyl).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; Nagoya University; Ishihara, Kazuaki; Hatano, Manabu; (20 pag.)JP2019/26618; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2215-78-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2215-78-3, name is (4-Phenoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

PRODUCTION EXAMPLE 4 Production of Compound (35) by Production Process E To a solution of 0.46 g of 4-(3,3-dichloro-2-propenyloxy)-2,6-dichlorophenol, 0.32 g of p-phenoxybenzyl alcohol and 0.46 g of triphenylphosphine dissolved in 10 ml of tetrahydrofuran was added dropwise a solution of 0.35 g of diisopropylazodicarboxylate dissolved in 5 ml of tetrahydrofuran, while stirring at room temperature. After stirring at room temperature for 12 hours, the reaction mixture was concentrated, and then mixed with 20 ml of diethyl ether. The precipitate was filtered, and the filtrate was concentrated. The residue was subjected to silica gel chromatography, which afforded 0.51 g of 3,5-dichloro-4-(4-phenoxybenzyl)-1-(3,3-dichloro-2-propenyloxy)benzene (68% yield), nD25.5 1.6084.

According to the analysis of related databases, 2215-78-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sumitomo Chemical Company, Limited; US5872137; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts