Month: June 2021

Synthetic Route of 1777-82-8, Adding some certain compound to certain chemical reactions, such as: 1777-82-8, name is (2,4-Dichlorophenyl)methanol,molecular formula is C7H6Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1777-82-8.

General procedure: Runp-nSTDP (40mg, 0.84mol %) were stirred in 5mL ofacetonitrile taken in a round bottomed flask equipped witha condenser and a stirring bar. The substrate (0.5mmol),oxidant (1mmol) was added to the stirring solution, andthen the mixture was refluxed at 80C under atmosphericpressure of air. The reaction progress was monitored by GC.After completion of the reaction, the nanocatalyst was separatedfrom the reaction mixture by simple centrifugation,washed with the adequate amount of acetonitrile (5ml) andH2O(5ml). Later on, the products were extracted with Et2Oand purified on a silica gel column.

According to the analysis of related databases, 1777-82-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Haghshenas Kashani, Sara; Moghadam, Majid; Tangestaninejad, Shahram; Mirkhani, Valiollah; Mohammadpoor-Baltork, Iraj; Catalysis Letters; vol. 148; 4; (2018); p. 1110 – 1123;,
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Application of 13807-89-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13807-89-1, name is 2-((4-Methoxybenzyl)oxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Methanesulfonic acid 2-(4-methoxybenzyloxy) ethyl ester A solution of 2-(4-methoxybenzyloxy)ethanol (Intermediate 18) (2.26g, 12.4mmol) and diisopropylethylamine (6.7ml, 37.2mmol) in 15mL dry DCM, cooled to O0C under a nitrogen atmosphere, was treated dropwise with a solution of methanesulfonyl chloride (1.5ml_, 18.6mmol) in 1OmL DCM. The reaction mixture was stirred at RT for 16h, then water was added. The organic layer was separated, dried (MgSO4) and concentrated. Purification by chromatography (Redisep cartridge) eluting with ethyl acetate/cyclohexane afforded the title compound as an oil. Yield: 2.5g (77%) LC-MS (Method 4): Rt 2.81 mins, molecular ion not observed

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13807-89-1, 2-((4-Methoxybenzyl)oxy)ethanol.

Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2008/96093; (2008); A1;,
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Electric Literature of 172023-97-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 172023-97-1 as follows.

Step 2: 3-bromo-5-(trifluoromethyl)benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate To a stirred solution of (3-bromo-5-(trifluoromethyl)phenyl)methanol (567 mg, 2.223 mmol) in DMF (5 mL) at RT under nitrogen was added CU (360 mg, 2.223 mmol) and the reaction mixture heated at 50 C. for 20 hours. Tert-butyl piperidin-4-yl carbamate (445 mg, 2.223 mmol) was added and the reaction mixture stirred at 50 C. for 3 hours. On cooling to RT the mixture was diluted with DCM and washed with a saturated solution of sodium bicarbonate, a saturated solution of brine, and the organic portion was dried over MgSO4 filtered and concentrated under reduced pressure. Purification was carried out by chromatography on silica using 0-100% EtOAc in Hexanes as eluent to afford the title product; LC-MS: Rt 1.59 mins; MS m/z 427.2 [M-tBu]+; Method 2minLowPHv03

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,172023-97-1, its application will become more common.

Reference:
Patent; Novartis AG; Legrand, Darren Mark; Furminger, Vikki; Thomson, Christopher; Hughes, Owen Rhys; Stanley, Emily; US2014/171403; (2014); A1;,
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Application of 4654-39-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4654-39-1, name is 2-(4-Bromophenyl)ethanol. A new synthetic method of this compound is introduced below.

Triethylamine (5.2 mL, 37.3 mmol) was added to a solution of 4-bromophenethyl alcohol (5.0 g, 24.9 mmol) in CH2Cl2 (200 ml), and the resulting solution was cooled to 0 C. with an ice bath. Methanesulfonyl chloride (2.7 ml, 34.8 mmol) was added dropwise to the reaction mixture, and the resulting solution was allowed to warm slowly to room temperature overnight. The solution was washed with 0.1 N HCl and brine, and the combined organic extracts were dried over anhydrous MgSO4(s) and filtered, and the solvent was removed under reduced pressure. The crude yellow solid was purified by flash chromatography (silica gel, 70% v/v hexanes in CH2Cl2) to give mesylate 18 as a white solid in 98% yield. 1H NMR (CDCl3, 400 MHz) delta 7.46 (d, J) 8.5 Hz, 2H), 7.12 (d, J) 8.6 Hz, 2H), 4.39 (t, J) 6.9 Hz, 2H), 3.02 (t, J) 6.7 Hz, 2H), 2.89 (s, 3H) ppm; 13C NMR (CDCl3, 125 MHz) delta 135.55, 132.52, 130.92, 121.70, 69.83, 37.68, 35.31 ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4654-39-1, 2-(4-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Wisconsin Alumni Research Foundation; Raines, Ronald T.; Tam, Annie; Soellner, Matthew B.; US8410247; (2013); B2;,
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Synthetic Route of 23377-40-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, molecular weight is 300.52, as common compound, the synthetic route is as follows.

Compound 315: To a solution of 1H-tetrazole (0.415 g, 5.92 mmol) in 25 ml ether and 10 ml acetonitrile diisopropylamine (0.93 ml, 0.726 g, 7.03 mmol) was added. The precipitate was filtered off, washed with ether and dried under vacuum to give diisopropylammonium tetrazolide.Compound 316: 3-(hexadecyloxy)propan-1-ol (0.301 g, 1.00 mmol) and diisopropylammonium tetrazolide (0.115 g, 0.67 mmol) were coevaporated with DCM-AcCN mixture(10:10) 3 times. Dried mixture was dissolved in 7 ml DCM and added 3- ((bis(diisopropylamino)phosphino)oxy)propanenitrile (0.673 ml, 2.120 mmol). After 1 hour stirring at room temperature 1 ml methanol was added and stirred for 15 minutes. Then reaction was concentrated under vacuum; diluted with 10%TEA solution in EtOAc (100 ml) and washed with 10%NaHCO3 solution (2 x 50 ml) and water (2 x 50 ml); dried over anhydrous MgSO4; filtered off and evaporated. The crude product was purified with column chromatography using Hexanes:EtOAc:TEA (10:4:0.5). 1H-NMR: 3.89-3.54 (m, 6H); 3.49 (t, 2H, J=6.4 Hz); 3.39 (t, 2H, J=6.4Hz); 2.63 (dt, 2H, J=1.6, 6.4 Hz); 1.89-1.83 (m, 1H); 1.57-1.51 (m, 1H); 1.24 (s, 24H); 1.19-1.16 (m, 16H); 0.87 (t, 3H, J=6.4 Hz).

The chemical industry reduces the impact on the environment during synthesis 23377-40-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; EMORY UNIVERSITY; LIOTTA, Dennis, C.; PAINTER, George, R.; BLUEMLING, Gregory, R.; DE LA ROSA, Abel; (408 pag.)WO2016/145142; (2016); A1;,
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Reference of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.

45.6 g of 2-amino-1,3-dihydroxypropane was mixed with 113 mL of formic acid solution,Then add 90 mL of 37% formaldehyde solution.The mixture was stirred at room temperature for 2h,The reaction was then warmed to 80 C,And kept at this temperature overnight.When the temperature reaches 80 , there will be a lot of gas discharge. After the reaction was completed, it was cooled to room temperature. 60 mL of 37% strength hydrochloric acid was added and stirred for 1 h.Solid sodium hydroxide was added to adjust the pH of the solution to 12, the mixture was distilled under reduced pressure,Add a lot of methanol.At this point the white precipitate generated in the system filter, the filtrate was distilled off under reduced pressure,The concentrated initial product was dissolved in trichloromethane and dried over anhydrous magnesium sulfate.In the conditions of 100 -102 / 100Kpa by distillation,40.9 g was obtained2-N, N-dimethyl-1,3-dihydroxypropane,The yield was 68.65%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; University of Science and Technology Beijing; Gong Aijun; Yang Jing; Qiu Lina; Xie Yanping; Zhao Yunbo; (9 pag.)CN105198773; (2017); B;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H18O2

EXAMPLE 5 1,3-bis-(4-nitrophenoxy)-2,2,4-trimethylpentane 146 g (1 mol) 2,2,4-trimethyl-1,3-dihydroxypentane, 346.5 g (2.2 mols) 4-nitrochlorobenzene and 140 g powdered sodium hydroxide were reacted using the same procedure described in Example 1 in 600 ml DMSO. Yield: 265 g (68.3% of the theoretical) Mp.: 95-96 C. (beige powder)

With the rapid development of chemical substances, we look forward to future research findings about 144-19-4.

Reference:
Patent; Bayer Aktiengesellschaft; US4820866; (1989); A;,
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Application of 7589-27-7 ,Some common heterocyclic compound, 7589-27-7, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0197] To a stirred solution of the 2-(4-fluorophenyl) ethanol (200 mg, 1.43 mmol) in MeCN (4 mL) was added 2-iodoxybenzoic acid (1.2 g, 4.3 mmol). The resulting mixture was heated to 80 C. After stirred for 2 hrs, the mixture was cooled to room temperature, and filtered through a pad of celite. The filtrate was concentrated to afford the title compound as a pale yellow oil (197 mg, 100%) which was used in the next step without further purification. 1HNMR (400 MHz, CDCI3) 6 9.77 (t, J = 2.0 Hz, 1H), 7.22-7.14 (m, 2H), 7.10-7.01 (m, 2H), 3.70 (t, J = 2.0 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7589-27-7, 2-(4-Fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (157 pag.)WO2016/126869; (2016); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16545-68-9, name is Cyclopropanol. A new synthetic method of this compound is introduced below., Formula: C3H6O

Water (300 ml),Cyclopropanol (500 ml),N, N-diethyl-2,3,3,3-tetrafluoropropanamide (900 g, 4.47 mol),98% sulfuric acid (600 ml) was placed in the reaction flask,The temperature was raised to 130 C and refluxed for 12 hours.Reaction completed,Atmospheric distillation,Fractions of around 127 C were collected to give cyclopropyl 2,3,3,3-tetrafluoropropionate,The yield was 90%Purity 98.6%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16545-68-9, Cyclopropanol.

Reference:
Patent; Zhao, Manliang; (9 pag.)CN106278887; (2017); A;,
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Application of 202865-66-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, molecular weight is 205.02, as common compound, the synthetic route is as follows.

General procedure: 2-Halobenzyl tosylates 1a-e were prepared from the corresponding 2-halobenzyl alcohols according to the procedure of Wallace et al.38 p-TsCl (3.2 mmol) was added to a stirred solution of the 2-halobenzyl alcohol (2.7 mmol) in Et2O (15 mL) at 0 C. After addition of freshly powdered KOH (27 mmol) in small portions, the reaction mixture was stirred for 3 h at room temperature. The ethereal solvent was removed in vacuo and the reaction mixture was poured into water (50 mL). The precipitate formed was collected by filtration and purified by flash chromatography over silica gel.

Statistics shows that 202865-66-5 is playing an increasingly important role. we look forward to future research findings about (2-Bromo-5-fluorophenyl)methanol.

Reference:
Article; Omar, Mohamed A.; Conrad, Juergen; Beifuss, Uwe; Tetrahedron; vol. 70; 35; (2014); p. 5682 – 5695;,
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