Month: June 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H11ClO

General procedure: Compounds 2M-6M were prepared by a similar method. The synthesis of compound 6M is described below. 4,4?-Dihydroxydiphenyl (9.3 g, 0.05 mol) and 6-chloro-1-hexanol (15.1 g, 0.11 mol) were added to a solution of sodium hydroxide (4.4 g, 0.11 mol) in ethanol (200 mL, 95percent). The solution was heated to reflux for 20 h then was cooled and the solid salt was removed by filtration. The remaining solid was recrystallized from DMF/H2O to yield 15.6 g (81percent) of crystals.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Article; Chen, Cheng-Chih; Lin, Chih-Hung; Oriental Journal of Chemistry; vol. 34; 1; (2018); p. 125 – 133;,
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Reference of 162744-59-4, Adding some certain compound to certain chemical reactions, such as: 162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol,molecular formula is C7H5BrF2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 162744-59-4.

((4-bromo-2,6-difluorobenzyl)oxy)(tert-butyl)dimethylsilane A mixture of (4-bromo-2,6-difluorophenyl)methanol (7.5 g, 33.5 mmol), TBDMSCl (10.8 g, 67.0 mmol) and imidazole (3.0 g, 40.2 mmol) in DMF (70 mL) was stirred at 20C under N2 atmosphere for 2 hours, quenched with water (350 mL) and extracted with EtOAc (200 mL*3). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography to give Compound 17A (colorless oil, 10.2 g, 90% yield). LCMS (ESI) m/z: 338 (M+H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162744-59-4, (4-Bromo-2,6-difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Medshine Discovery Inc.; LONG, Chaofeng; CHEN, Shuhui; CHEN, Xiaoxin; LUO, Yunfu; LIU, Zhuowei; PAN, Jianfeng; (56 pag.)EP3287453; (2018); A1;,
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Reference of 68327-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediates 10: N-[(1S,2S)-2-Hydroxycyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide Triethylamine (1.52 ml, 10.90 mmol), 3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol (0.59 g, 4.36 mmol) and EDC (0.84 g, 4.36 mmol) were added to a solution of (1R,2S)-2-aminocyclopentan-1-ol hydrochloride (CAS number 137254-03-6; 0.50 g, 3.63 mmol) and 2-(2H-1,2,3-triazol-2-yl)benzoic acid (CAS number 1001401-62-2; 0.76 g, 4.00 mmol) in DCM (10 ml). The reaction was stirred at room temperature for 18 hours and then diluted with DCM (50 ml) and washed with a saturated solution of sodium bicarbonate (2×20 ml). The crude product was purified by column chromatography (silica, 0-100% ethyl acetate/petrol) to afford the title compound. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.36-1.59 (m, 3H), 1.62-1.88 (m, 3H), 3.79-3.93 (m, 1H), 3.94-4.10 (m, 1H), 4.29-4.39 (m, 1H), 7.49-7.58 (m, 1H), 7.58-7.67 (m, 2H), 7.71-7.82 (m, 2H), 8.05 (s, 2H) MS ES+: 273 Intermediates 11: N-[(1S,2S)-2-Hydroxycyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide Prepared according to the procedure for N-[(1S,2S)-2-hydroxycyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide (Intermediate 10) from 2-(2H-1,2,3-triazol-2-yl)benzoic acid (CAS number 1001401-62-2; 531 mg, 2.81 mmol), (1S,2S)-2-aminocyclopentan-1-ol hydrochloride (CAS number 68327-04-8; 368 mg, 2.67 mmol) and DIPEA (1401 mul, 8.02 mmol) to afford the title compound. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.33-1.48 (m, 2H), 1.49-1.79 (m, 3H), 1.83-1.97 (m, 1H), 3.80-3.88 (m, 1H), 3.89-3.98 (m, 1H), 4.57-4.67 (m, 1H), 7.43-7.55 (m, 2H), 7.56-7.67 (m, 1H), 7.73-7.83 (m, 1H), 8.03 (s, 2H), 8.09-8.23 (m, 1H) MS ES+: 273

According to the analysis of related databases, 68327-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; Fieldhouse, Charlotte; Glen, Angela; Maine, Stephanie; Fujimoto, Tatsuhiko; Robinson, John Stephen; US2015/232460; (2015); A1;,
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Reference of 589-98-0, Adding some certain compound to certain chemical reactions, such as: 589-98-0, name is 3-Octanol,molecular formula is C8H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 589-98-0.

General procedure: Compound 5 was dissolved in alcohol (13±16 equiv) and heated to 100C for 3 h in the presence of a catalytic amount of H2SO4 (0.1 equiv). Complete dissolution occurred while heating. The reaction was quenched by adding a saturated solution of NaHCO3 in water and the mixture was extracted with EtOAc. The organic layers were combined, and the solvent was evaporated under reducedpressure at 40C. The residual alcohol was removed by vacuum distillation. The crude residue was purified by flash column chromatography with appropriate eluents and a gradient. Diheptyl 2-[(4-methoxyphenoxy)methyl]pyrimidine-4,6-dicarboxylate (6a). Generalprocedure I was followed. Compound 5 (73 mg, 0.20 mmol), 1-heptanol (0.50 mL, 3.2 mmol,16 equiv), H2SO4 (1 muL, 0.03 mmol, 0.1 equiv). Flash chromatography eluents: n-hexane (A),Et2O (B); gradient: 8%66% B×10 CV. Compound 6a was isolated as a dark yellow oil (81mg, 0.16 mmol, 80% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 589-98-0, 3-Octanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Provenzani, Riccardo; Tarvainen, Ilari; Brandoli, Giulia; Lempinen, Antti; Artes, Sanna; Turku, Ainoleena; Jaentti, Maria Helena; Talman, Virpi; Yli-Kauhaluoma, Jari; Tuominen, Raimo K.; Boije af Gennaes, Gustav; PLoS ONE; vol. 13; 4; (2018);,
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Synthetic Route of 4415-73-0, Adding some certain compound to certain chemical reactions, such as: 4415-73-0, name is 1,1-Cyclobutanedimethanol,molecular formula is C6H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4415-73-0.

Add 2.6 ml of an 11.25N sodium hydroxide solution at 70 C. to a solution of 1.72 g (14.85 mmol) of cyclobutane-1,1-diyldimethanol [F. X. Tavares, J. Med. Chem. 2004, 47 (21), 5057-5068] in 20 ml of toluene, 8 ml of 1,2-dimethoxyethane and 8 ml of water. After adding 0.10 g (0.30 mmol) of tetra-n-butylammonium hydrogen sulphate and 1.00 g (2.97 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine, stir the reaction mixture at 70 C. for 17 h. After cooling to room temperature, adjust to pH 7 with concentrated hydrochloric acid. Extract three times with 50 ml of dichloromethane each time. Wash the combined organic extracts with satd. sodium chloride solution, dry over sodium sulphate and filter. Concentrate the filtrate under reduced pressure. Stir the residue in acetonitrile, filter and purify the filtrate by means of preparative RP-HPLC (gradient: water/acetonitrile). 0.30 g (24% of theory) of the desired product are obtained. LC-MS (Method 3): Rt=2.67 min; m/z=417 (M+H)+ 1H-NMR (400 MHz, DMSO-d6): delta=8.58 (s, 1H), 7.56-7.54 (m, 2H), 7.42-7.37 (m, 5H), 7.04-6.99 (m, 2H), 4.56 (t, 1H), 4.30 (s, 2H), 3.81 (s, 3H), 3.21 (d, 2H), 1.77-1.58 (m, 6H).

According to the analysis of related databases, 4415-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/124665; (2011); A1;,
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Reference of 66582-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66582-32-9, name is 3-(Benzyloxy)-2,2-dimethylpropan-1-ol, molecular formula is C12H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of oxalyl chloride (40 mmol,2 eq), in dichloromethane (20 mL) at -78C, was added DMSO (80 mmol, 4 eq) in dichloromethane(20 mL) dropwise. After stirring during 30 min, a solution of monobenzylated diol (20 mmol, 1 eq)in dichloromethane (20 mL) was added dropwise. The mixture was stirred 2 h, and triethylamine (6eq) in CH2Cl2 (15 mL) was added dropwise. The mixture was allowed to reach room temperature,and quenched with 50 mL of water. The organic layers were washed with a solution of saturated NaCl, then dried over anhydrous MgSO4, filtered and concentrated in vacuo. The yellow oil was purified by flash chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 66582-32-9, 3-(Benzyloxy)-2,2-dimethylpropan-1-ol.

Reference:
Article; Chalopin, Thibaut; Jebali, Khaoula; Gaulon-Nourry, Catherine; Denes, Fabrice; Lebreton, Jacques; Mathe-Allainmat, Monique; Tetrahedron; vol. 72; 2; (2016); p. 318 – 327;,
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Electric Literature of 349-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

DL-1-phenylethanol (122 mg, 1.0 mmol), cat. [Ir] (5.3 mg, 0.01 mmol, 1 mol%) and tert-amyl alcohol (1 mL) were successively added to a 5 mL round bottom flask. The reaction mixture was refluxed in air for 6 hours and then cooled to room temperature. Then, cesium carbonate (33 mg, 0.1 mmol, 0.1 equiv.) And 4-trifluoromethylbenzyl alcohol (194 mg, 1.1 mmol) were added, refluxed in air for 6 hours and then cooled to room temperature. The solvent was removed by rotary evaporation and then the title compound was obtained by column chromatography (developing solvent: petroleum ether / ethyl acetate) in 83%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 349-95-1, (4-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; Nanjing University of Science and Technology; Wang, Rongzhou; Fan, Hongjun; Li, Feng; (18 pag.)CN106478325; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 161446-90-8, name is 3-Chloro-4-fluorobenzyl Alcohol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

Intermediate 50 (1.25 mmol), triphenylphosphine (1.87 mmol) and carbon tetrabromide (1.87 mmol) were stirred in anhydrous DCM, under nitrogen for 3 hours. The solvent was removed under reduced pressure and the crude material was purified by chromatography on silica gel to give intermediate 51, which was a colourless oil. Intermediate 51 was characterized by the following spectroscopic data: 1H NMR (DMSO-d6, 400 MHz) (ppm) 4.43 (s, 2H), 7.13 (t, J=8.37 Hz, 1H), 7.26-7.28 (m, 1H), 7.44-7.47 (d, J=6.70 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 161446-90-8, 3-Chloro-4-fluorobenzyl Alcohol.

Reference:
Patent; Idenix Pharmaceuticals, Inc.; US2009/60866; (2009); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3344-77-2, name is 12-Bromododecan-1-ol. A new synthetic method of this compound is introduced below., Safety of 12-Bromododecan-1-ol

Tetrahydro-2-(12-bromododecanoxy)-2H pyran To a solution of 12-bromo-1-dodecanol (1 mole) in dichloromethane containing pyridinium p-toluenesulfonate (P-TSA) is added dihydropyran (2 moles). The reaction mixture is stirred for 24 hours and then washed twice with water and dried over anhydrous MgSO4. The dichloromethane is removed under reduced pressure. If necessary the resulting product is purified by chromatography on silica gel. Coupling of polyethylene glycol to the terahydropyran derivative The tetrahydropyran derivative described above, dissolved in dry benzene, is added to a solution of polyethylene glycol (1 mole) in dry benzene containing NaH (1 mole).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3344-77-2, 12-Bromododecan-1-ol.

Reference:
Patent; Protein Delivery, Inc.; US6191105; (2001); B1;; ; Patent; Protein Delivery, Inc.; US5681811; (1997); A;,
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Reference of 722-92-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 12a-e in DMSO (500 L) were added 4-(hexafluoro-2-hydroxyisopropyl)aniline (2 eq.)and N,N-diisopropylethylamine (2 eq.) at room temperature. The mixture was stirred for 15 min at 100 C,then poured into dilute hydrochloric acid and extracted with EtOAc. The organic layer washed with brine,dried over sodium sulfate and concentrated. The residue was purified by recrystallization from MeOH.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kaitoh, Kazuma; Toyama, Hirozumi; Hashimoto, Yuichi; Fujii, Shinya; Heterocycles; vol. 95; 1; (2017); p. 547 – 556;,
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