Share a compound : 346-06-5

Statistics shows that 346-06-5 is playing an increasingly important role. we look forward to future research findings about (2-(Trifluoromethyl)phenyl)methanol.

Electric Literature of 346-06-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

General procedure: To a 100 mL two-necked flask was added substituted benzylalcohol or 4,6-dimethylpyrimidine-2-thiol (2.60 mmol), NaOH (6.40 g, 1.60 mmol) and dimethylsulfoxide (30 mL). The flask was vacuumed and flushed three times with nitrogen. Then the solutionof 8 (0.20 g, 0.87 mmol) in dimethylsulfoxide (510 mL) was added, and the resulting mixture was heated to 80 C and kept at that temperature for approximately 12 h until the completion of the reaction (monitored by TLC). Subsequently, the mixture was cooled to room temperature and diluted with ethyl acetate (100 mL). The mixture was washed with brine to pH 7, and the organic phase was dried with anhydrous sodium sulfate. The organic phase was concentrated to get crude product, which was purified by column chromatography (ethyl acetate/ petroleumether 1:30 as eluent) to get 4a?ac in yields of 27.3?75.1percent.#10;#10;

Statistics shows that 346-06-5 is playing an increasingly important role. we look forward to future research findings about (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Article; Lu, Huan-Huan; Xue, Ping; Zhu, Yuan-Yuan; Ju, Xiu-Lian; Zheng, Xiao-Jiao; Zhang, Xun; Xiao, Ting; Pannecouque, Christophe; Li, Ting-Ting; Gu, Shuang-Xi; Bioorganic and Medicinal Chemistry; vol. 25; 8; (2017); p. 2491 – 2497;,
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Introduction of a new synthetic route about 534-03-2

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Electric Literature of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

To a solution of 2-amino-1,3-propanediol (S2, 299 mg, 3.28 mmol, 1.0 equiv) in MeCN (10 mL), K2CO3 (2.27 g, 16.4 mmol, 5.0 equiv) and benzyl bromide (0.98 mL, 1.4 g, 8.3 mmol, 2.5 equiv) were added at room temperature. The reaction mixture was stirred at this temperature for 18 h and then diluted with water (10 mL). The aqueous layer was extracted with EtOAc (3 × 10 mL) and the combined organics were dried over Na2SO4. The solvent was removed under reduced pressure and the resultant residue was purified by column chromatography (SiO2, petroleum ether/EtOAc 1:1) to yield 716 mg (2.64 mmol, 80%) of S3 as a white solid. TLC Rf 0.20 (petroleum ether/EtOAc 1:1); mp 113 C; 1H NMR (300 MHz, C6D6): 2.30 (bs, 2H, OH), 2.93 (tt, 1H, J = 7.5, 5.9 Hz, 2-H), 3.37 (dd, 2H, J = 10.8, 5.9 Hz, 1-Ha, 3-Ha), 3.48 (dd, 2H, J = 10.8, 7.5 Hz, 1-Hb, 3-Hb), 3.53-3.66 (m, 4H, CH2Ph), 7.01-7.32 (m, 10H, Ph-H); 13C NMR (76 MHz, C6D6): 54.4, 60.2, 60.3, 127.4, 128.7, 129.2, 140.1; IR (ATR) nu 3245, 1493, 1451, 1049, 1025, 999, 741, 730, 695; UV (MeCN) lambdamax (log epsilon) 206 (4.28), 259 (2.77); MS (ESI+) m/z 272.2 (M+H+), 294.2 (M+Na+); HRMS (ESI+) m/z calcd for C17H21NNaO2 294.1465 (M+Na+), found 294.1466.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ries, Oliver; Bueschleb, Martin; Granitzka, Markus; Stalke, Dietmar; Ducho, Christian; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1135 – 1142;,
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Brief introduction of 1-(4-Methoxyphenyl)ethanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3319-15-1, 1-(4-Methoxyphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Application of 3319-15-1 ,Some common heterocyclic compound, 3319-15-1, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In assembling the magnetic force of the solder 25 ml glass tube by adding 1 mmol of 1 – (methoxyphenyl) ethanol (formula (1 – 5)), 0.1 mmol of I2, 0.1 Mmol of Fe (NO3)3· 9 H2O, 2 ml of DMSO, oxygen is used for replacement in the glass tube after the air sealing glass tube, will then be sealed glass tube is put into the pre-heating to 130 C the pot of the oil bath, and opening of the magnetic stirrer, reaction 12 h after, is taken out of the sealed glass tube, to be its cooling to room temperature, the reaction solution is added in the quenching reaction, then the concentration of 0.1 mol/L of sodium hydroxide solution to adjust the pH to 11 the left and right, for washing three times with ethyl acetate, the aqueous phase is in a concentration of 0.1 mol/L hydrochloric acid solution to pH value to 2 the left and right, then the extraction three times with ethyl ether, the merging of the three times of the ether extract, reducing pressure and ethyl ether, then column chromatography, using ethyl acetate/petroleum ether volume ratio 1:25 of the mixed solution is the eluant, collecting the eluant containing the compound, evaporate the solvent to get the product to the anisic acid, separating the yield is 73%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3319-15-1, 1-(4-Methoxyphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Li Meichao; Wang Yuru; Xu Liang; Shen Zhenlu; (9 pag.)CN108821931; (2018); A;,
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Sources of common compounds: 33524-31-1

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33524-31-1, (2,5-Dimethoxyphenyl)methanol.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 33524-31-1

2,5-dimethoxybenzyl alcohol (1.68 g, 10 mmol) was dissolved in 50 mLAnhydrous methylene chloride, stirred for 10 minutes in an ice bath,Phosphorus tribromide (1.0 g, 3.7 mmol) was slowly added dropwise,After the addition was complete, continue to react for 1 hour under ice bath.The reaction mixture was diluted with 200 mL of methylene chloride and washed with water (50 mL × 3)Saturated brine (100 mL × 1), dried over anhydrous sodium sulfate, filtered,After the solvent was evaporated to dryness under reduced pressure, the crude product was purified by column chromatography2,5-dimethoxybenzyl bromide (2.2 g, 96% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33524-31-1, (2,5-Dimethoxyphenyl)methanol.

Reference:
Patent; Beijing Zhuokai Biological Co., Ltd.; Xie Zuolei; (46 pag.)CN107353239; (2017); A;,
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Analyzing the synthesis route of 96-35-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,96-35-5, its application will become more common.

Synthetic Route of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3.85 g of silver perchlorate (18.6 mmol) are added to a solution of 8,8-dibromobicyclo[5.1.0]octane 16 (2.5 g, 9.3 mmol) and methyl glycolate (6.35 ml, 83.9 mmol) dissolved in 5 ml of anhydrous toluene in a dry round-bottomed flask under Ar protected from light by an aluminum film. The reaction mixture is stirred at ambient temperature for 1 h 30 and then the silver salts are filtered off through a sintered glass funnel and washed with AcOEt. The solution is concentrated under vacuum to give a viscous brown oil which is purified by chromatography on silica gel (cyclohexane/2-15% AcOEt) to produce 17 in the form of a yellow oil (w=1.7 g, i.e. 66% yield).1H NMR (CDCl3, 200 MHz): delta (ppm) 0.7-2.2 (m, 8H, H4-4′-5-5′-6-6′-7-7′); 2.28 (m, 1H, H8); 2.70 (ddd, J=5.0-11.5-23.5 Hz, 1H, H8′); 3.72 (s, 3H, OMe); 3.94 (d, J=16.5 Hz, 1H, H9); 4.10 (dd, J=5.0-10.0 Hz, 1H, H3); 4.23 (d, J=16.5 Hz, 1H, H9′); 6.20 (dd, J=4.0-11.5 Hz, 1H, H1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,96-35-5, its application will become more common.

Reference:
Patent; COMMISSARIAT A L’ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES; US2011/118484; (2011); A1;,
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Extracurricular laboratory: Synthetic route of 2-(4-Fluorophenyl)ethanol

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7589-27-7, 2-(4-Fluorophenyl)ethanol.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C8H9FO

Example 1 Scheme A, step a: (R)-alpha-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol (3) A suitable reactor maintained under nitrogen was charged with 4-fluorophenethyl alcohol (2.6 kg, 18.6 mol) and 18 L of methylene chloride. The stirred solution was cooled to and maintained at 0-5°C while triethylamine 2.85 kg (28.2 mol) was added fairly rapidly. The reaction temperature was maintained at 0-5 °C while adding methanesulfonyl chloride (2.5 kg, 21.8 mol) over 1 hour. The stirred reaction mixture was maintained at 0-5°C for 1 hour, then it was warmed to room temperature within approximately 2 hours. The reaction mixture was diluted with a solution of 0.5 kg of 33percent hydrochloric acid in 10 L of water. The organic phase was separated and washed with a solution of 0.2 kg of 33percent hydrochloric acid in 5 L of water. Both acidic extracts were combined and extracted with 5 L of methylene chloride. Both organic phases were combined, washed with 2 x 15 L of water, then dried with sodium sulfate (2 kg). Drying agent was filtered off and washed with 2 x 5 L of methylene chloride. The majority of the solvent was boiled off at atmospheric pressure, with the final amount distilled off at 35°C/500 torr to give 4-fluorophenethyl alcohol methanesulfonate (4.17 kg.)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7589-27-7, 2-(4-Fluorophenyl)ethanol.

Reference:
Patent; Aventis Pharmaceuticals, Inc.; Hoechst Marion Roussel Deutschland GmbH; EP1734037; (2006); A2;,
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The origin of a common compound about 6214-44-4

According to the analysis of related databases, 6214-44-4, the application of this compound in the production field has become more and more popular.

Electric Literature of 6214-44-4, Adding some certain compound to certain chemical reactions, such as: 6214-44-4, name is (4-Ethoxyphenyl)methanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6214-44-4.

EXAMPLE 13 This Example illustrates the preparation of 4-ethoxybenzyl chloride. 4-Ethoxybenzyl alcohol (5 g) and concentrated hydrochloric acid (8.5 cm3) were vigorously stirred together for 30 minutes. The 2 phases were then allowed to separate, and the lower layer separated off, and diluted with chloroform. The organic solution was dried over anhydrous magnesium sulphate, and removal of the solvent by evaporation gave 4-ethoxybenzyl chloride (5.6 g). (This product is not stable on keeping, so was converted immediately to the phosphonium salt–see Example 12). 1 H nmr (CDCl3) ppm: 1.3 (t,3H); 4.0 (q,2H); 4.6 (s,2H); 6.9 (d,2H); and 7.3 (d,2H).

According to the analysis of related databases, 6214-44-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Imperial Chemical Industries PLC; US4788348; (1988); A;,
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A new synthetic route of Diethyl 2,2-bis(hydroxymethyl)malonate

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20605-01-0, Diethyl 2,2-bis(hydroxymethyl)malonate, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 20605-01-0, Diethyl 2,2-bis(hydroxymethyl)malonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Diethyl 2,2-bis(hydroxymethyl)malonate, blongs to alcohols-buliding-blocks compound. name: Diethyl 2,2-bis(hydroxymethyl)malonate

Diethyl 2-(tert-butyldimethylsilyloxymethyl)-2-hydroxymethylmalonate (15). Diethyl 2,2-bis(hydroxymethyl)malonate (28.3 mmol; 6.23 g) was coevaporated twice from dry pyridine and dissolved in the same solvent (20 mL). tert-Butyldimethylsilyl chloride (25.5 mmol; 3.85 g) in dry pyridine (10 mL) was added portionwise. The reaction was allowed to proceed for 4 days. The mixture was evaporated to a solid foam, which was then equilibrated between water (200 mL) and DCM (4×100 mL). The organic phase was dried on Na2SO4. The product was purified by silica gel chromatography eluting with 10% ethyl acetate in DCM. The yield was 78%. 1H NMR (CDCl3) delta 4.18-4.25 (m, 4H, OCH2Me), 4.10 (s, 2H, CH2OSi), 4.06 (s, 2H, CH2OH), 2.63 (br s, 1H, OH), 1.26 (t, J=7.0 Hz, 6H, OCH2CH3), 0.85 (s, 9H, Si-SMe3), 0.05 (s, 6H, Me-Si). 13C NMR (CDCl3) delta 169.2 (CO), 63.3 (CH2OH), 62.8 (CH2OSi), 61.6 (spiro C), 61.4 (OCH2Me), 25.6 [C(CH3)3], 18.0 (Si-CMe3), 14.0 (OCH2CH3), -3.6 (Si-CH3). MS [M+H]+ obsd. 335.7, calcd. 335.2; [M+Na] obsd. 357.6, calcd. 357.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20605-01-0, Diethyl 2,2-bis(hydroxymethyl)malonate, and friends who are interested can also refer to it.

Reference:
Patent; Alios BioPharma Inc.; US2009/176732; (2009); A1;,
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Sources of common compounds: 558-42-9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 558-42-9, 1-Chloro-2-methyl-2-propanol.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C4H9ClO

To a mixture of 1-chloro-2-methylpropan-2-ol (2.2 g, 20.26 mmol) and potassium ethanethioate (6.94 g, 60.8 mmol) in DMF (20 mL) was added 100 mg of sodium bromide and the resulting mixture was heated at 50° C. for 18 hours. The mixture was then poured into water and extracted with EtOAc. The acetate layer was washed with water, brine, dried with MgSO4 and concentrated under reduced pressure to provide 3.4 g of the title compound

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
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Some tips on Sodium isethionate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1562-00-1, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 1562-00-1, Sodium isethionate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1562-00-1, blongs to alcohols-buliding-blocks compound. SDS of cas: 1562-00-1

EXAMPLE 2 [0038] Ethionic acid, 206 g, is diluted with 800 mL of deionized water and heated to reflux for three hours to complete the hydrolysis to an aqueous solution containing isethionic acid and sulfuric acid, to which 80 g of sodium sulfate is added. About 120 g of calcium hydroxide is added slowly to bring the pH to 8-9 and a white slurry of calcium sulfate is formed. After filtration and washing with deionized water, an aqueous solution of sodium isethionate is obtained. [0039] Into a 2 L autoclave is added the solution of sodium isethionate, and 2 g of sodium hydroxide. The solution is then saturated with ammonia to about 25% of ammonia. Ammonolysis is carried out at 220 C. under the autogenous pressure of about 140 bar for 2 hrs. HPLC analysis indicates the formation of 110 g of taurine in the solution. After removal of the excess ammonia, sulfuric acid is used to liberate taurine to yield a mixture of taurine and sodium sulfate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1562-00-1, its application will become more common.

Reference:
Patent; Hu, Songzhou; US2015/210633; (2015); A1;,
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