Month: June 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Ethylamino)ethanol

Reference Example 19 tert-Butyl ethyl(2-hydroxyethyl)carbamate (0438) (0439) To a mixture of 2-(ethylamino)ethanol (8.91 g) and ethyl acetate (100 mL) was added di-tert-butyl dicarbonate (21.8 g) under ice-cooling. After stirring at room temperature for 3 days, the mixture was washed with saturated brine (100 mL), and dried over anhydrous magnesium sulfate. Concentration under reduced pressure gave the title compound (19.0 g) as a colorless oil. (0440) 1H-NMR (CDCl3): 1.11 (3H, t, J=7.0 Hz), 1.47 (9H, s), 3.27 (2H, q, J=7.0 Hz), 3.37 (2H, t, J=5.2 Hz), 3.73 (2H, q, J=5.2 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; AKIYAMA, Yohko; KURASAWA, Takashi; BANDO, Hiroto; NAGAHARA, Naoki; (88 pag.)US2016/128945; (2016); A1;,
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Reference of 2009-83-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2009-83-8, name is 6-Chlorohexan-1-ol. A new synthetic method of this compound is introduced below.

2.2 Preparation of 6-hydroxyhexyl 3,5-dinitrobenzoate 357.70 g (1.686 MoI) of 3,5-dinitrobenzoic acid are suspended in 750 ml of 1-methyl-2- pyrrolidone. The suspension is stirred up to 500C. 386.36 g (4.599 MoI) of sodium hydrogen carbonate are added and the mixture was heated up to 900C. 22.50 g (0.150 MoI) of sodium iodide and 204.0 ml (1.533 MoI) of 6-chlorohexanol are added to the reaction mixture which is heated to 1000C for 1 h. After 1 h of reaction, the reaction is complete and the orange suspension is thrown on 2 I of ice and1 I of water. The product is filtrated, washed water and dried at 5O0C under vacuum for 24 h to give 425.0 g (91%) of 6-hydroxyhexyl 3,5-dinitrobenzoate as a rose powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ROLIC AG; WO2008/145225; (2008); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 612-16-8, name is (2-Methoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 612-16-8

The reactants used were o-methoxybenzyl alcohol (i.e., R1 in the formula (I) was ortho OCH3) 1.0 mmol(138.2 mg), experimental procedure and procedure with Example 1, aqueous ammonia (1.7 mol / L) 5.0 mL,The amount of catalyst used in cuprous chloride was 8 mol% (7.9 mg)TEMPO is used in an amount of 8 mol% (12.5 mg)The reaction temperature was 120 and the reaction time was 24h. The crude product was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to give the target product as 123.9 mgYield 93%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Patent; Zhejiang University of Technology; Zhang Guofu; Zhao Yiyong; Zhang Guihua; Ding Chengrong; Yu Yidong; Lv Jinghui; (10 pag.)CN106866326; (2017); A;,
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Synthetic Route of 756520-66-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

In a 100 mL single-necked flask,1- (3-fluoro-2,6-dichlorophenyl) ethanol 2.71g (0.013mol),15 mL of 1,4-dioxane,Ice bath in the cooling,Controlled at 1-5 C,1.2 g of sodium hydride (60% 0.03 mol) was added,About 15min,2.43 g (0.01 mol) of 4-chloro-6-bromo-quinazoline was added,After about 1 h at room temperature, the reaction solution was poured into 100 mL of H2O,With 10% hydrochloric acid transferred to neutral,filter,50% ethanol wash,3.3 g of a white solid,Yield 80%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.

Reference:
Patent; Southern Medical University; Wan Shanhe; Wang Guangfa; Wu Xiaoyun; Tian Yuanxin; Ye Ling; Li Zhonghuang; Zhang Tingting; Zhu Zhengguang; Jin Hong; Zhang Jiajie; (27 pag.)CN106565684; (2017); A;,
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Related Products of 62285-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 62285-58-9 as follows.

To a stirred solution of 2, 6-Dimethylbenzyl alcohol (9.94 g, 73 mmol) was added thionyl chloride (81.55 g, 685 mmol) at room temperature. The reaction mixture was stirred for 6 hours, concentrated under reduced pressure and used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62285-58-9, its application will become more common.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2005/18628; (2005); A1;,
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Synthetic Route of 311-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, molecular formula is C3H4BrF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 113 2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-methoxy-6-methylphenyl}azetidin-1-yl)-3,3,3-trifluoropropan-1-ol To a mixture of 1-[1-(3-azetidin-3-yl-5-chloro-2-methoxy-4-methylphenyl)ethyl]-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride (20 mg, 0.04 mmol, chrial intermediate from peak 1 of Example 1, step 7) and triethylamine (19 muL, 0.13 mmol) in acetonitrile (0.6 mL) was added 2-bromo-3,3,3-trifluoropropan-1-ol (from Synquest Labs, 9.2 mg, 0.048 mmol). N,N-dimethylformamide (0.3 mL) was added, which created a clear solution that was stirred at 70 C. overnight. The mixture was diluted water and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.6 mg (30%) of the desired product. The product was isolated as a mixture of diastereomers. LCMS calculated for C22H27ClF3N6O2 (M+H)+: m/z=499.2. Found: 499.1.

According to the analysis of related databases, 311-86-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Incyte Corporation; Li, Yun-Long; Yao, Wenqing; Combs, Andrew P.; Yue, Eddy W.; Mei, Song; Zhu, Wenyu; Glenn, Joseph; Maduskuie, JR., Thomas P.; Sparks, Richard B.; Douty, Brent; He, Chunhong; US2014/249132; (2014); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol, molecular formula is C12H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 4541-15-5

To a stirred solution of benzylated alcohol 10 (5.0 g, 25.77 mmol) in CH2Cl2 (80 mL) at rt was added TEMPO (40 mg, 2.57 mmol) and reaction the mixture was stirred for 10 min, followed by the addition of iodobis(acetoxy)benzene (9.13g, 28.35 mmol). The mixture was stirred for additional 1 h and then diluted with CH2Cl2 (20 mL). The mixture was then washed with sat. aq Na2S2O3 (15 mL) and extracted with CH2Cl2 (3 x 10 mL). The combined organic extracts were dried (Na2SO4) and concentrated in vacuo followed by purification with silica gel column chromatography using pet ether: ethylacetate (20:1) as eluent that afforded pure aldehyde 11. Yield: 95% (4.70 g), colorless oil; IR (CHCl3, cm-1): upsilonmax 696, 753, 1039, 1098, 1106, 1242, 1275, 1454, 1710, 2941; 1H NMR (200 MHz, CDCl3): delta 1.51-1.85(m, 5H), 2.34-2.61 (m, 2H), 3.47 (t, J = 5.9 Hz, 2H), 4.48 (s, 2H),7.26-7.43 (m, 5H), 9.75 (t, J = 1.6 Hz, 1H); 13C NMR (50 MHz, CDCl3): delta 18.9, 29.0, 43.4, 69.6, 72.8, 127.5, 128.2, 130.1, 138.3, 201.8; HRMS (ESI): calc.for [(C12H16O2)H](M+H) 193.1229, found 193.1223.

With the rapid development of chemical substances, we look forward to future research findings about 4541-15-5.

Reference:
Article; Gadakh, Sunita K.; Sudalai, Arumugam; Tetrahedron Letters; vol. 57; 1; (2016); p. 25 – 28;,
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Application of 426831-32-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 426831-32-5, name is (5-Fluoro-2-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A 25 ml round-bottomed flask was charged with 1.0 g (2.96 mmol) of 3-[bis(4-fluorophenyl)methyl]-4-piperidinone hydrochloride, 508 mg (3.26 mmol) of 5-fluoro-2-methoxybenzyl alcohol, 2.18 g (16.87 mmol) of diisopropylethylamine, 10 ml of dichloromethane and 889 mg (4.44 mmol) of EPPA, and the mixture was stirred at room temperature for about 4 days.. To the reaction mixture was added 10 ml of water, and the dichloromethane layer was separated.. The aqueous layer was extracted once again with 10 ml of dichloromethane, and then the organic layers were combined and washed with water (10 ml) followed by saturated brine (10 ml).. The mixture was dried over an anhydrous magnesium sulfate and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (50 g, n-hexane-ethyl acetate 4: 1, V/V) to obtain 642 mg of the title compound (yield: 49.4%). IR (KBr): 2484, 1729, 1604, 1508, 1224, 1159, 1028, 823, 720, 555cm-1.1H-NMR (CDCl3) delta: 2.38-2.61 (m, 4H), 2.74-2.78 (m, 1H), 2.85-2.90 (m, 1H), 3.26-3.31 (m, 1H), 3.52 (s, 2H), 3.74 (s, 3H), 4.58 (d, 1H, J=11.2Hz), 6.75 (m, 1H), 6.86-6.96 (m, 5H), 7.09-7.12 (m, 3H), 7.23-7.26 (m, 2H).

According to the analysis of related databases, 426831-32-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1460062; (2004); A1;,
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Application of 6338-55-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

2-(2,6- Dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione (1.0 equiv.), compound 13a/13b/13c (1.5 equiv.) and DIPEA (3.0 equiv.) in 2 mL DMF were stirred at 90 C overnight. Water was added to the reaction mixture and it was extracted with EtOAc. The organic phase was washed with water x1, brine x1, dried over Na2SO4, filtered and evaporated to dryness. The resulting mixture was purified by column chromatography using DCM and MeOH as eluents to afford 14a-c. (0329) [0151] 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-(2- hydroxyethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione (14a): 1H NMR (400 MHz, CDCl3) delta 8.19 (br s, 1H), 7.55-7.44 (m, 1H), 7.10 (d, J = 7.1 Hz, 1H), 6.91 (d, J = 8.5 Hz, 1H), 6.57 (t, J = 5.2 Hz, 1H), 4.91 (dd, J = 12.0, 5.4 Hz, 1H), 3.85-3.65 (m, 8H), 3.64-3.59 (m, 2H), 3.51-3.43 (m, 2H), 2.92-2.68 (m, 3H), 2.57 (br s, 1H), 2.18-2.07 (m, 1H) ppm.

According to the analysis of related databases, 6338-55-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOVENTURES, LLC; ZHENG, Guangrong; ZHOU, Daohong; ZHANG, Xuan; KHAN, Sajid; HE, Yonghan; ZHANG, Peiyi; (151 pag.)WO2019/144117; (2019); A1;,
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Electric Literature of 1124-63-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1124-63-6, name is 3-Cyclohexylpropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

3-Cyclohexyl-1-propanol (3.96 g, 27.8 mmol) was dissolved in DCM (90 mL) at 0 C. and treated sequentially with dimethyl sulfoxide (3.25 g, 41.7 mmol), N,N-diisopropylethylamine (8.98 g, 69.6 mmol) and sulfur trioxide pyridine complex (11 g, 69.6 mmol). After one hour, the reaction mixture was diluted with DCM (100 mL) and washed with 1N aqueous HCl (3×50 mL), saturated sodium bicarbonate (3×50 mL), and brine. The organic layer was dried over MgSO4, filtered, and concentrated to yield the title intermediate as a light yellow oil (3.8 g). 1H NMR (d6-DMSO, 300 MHz) delta (ppm): 9.72 (s, 1H), 3.65-3.72 (m, 2H), 2.46 (t, 2H), 1.65-1.73 (m, 3H), 1.51-1.56 (m, 2H), 1.14-1.48 (m, 4H), 0.85-0.96 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Patent; Long, Daniel D.; Church, Timothy J.; Jacobsen, John R.; Jiang, Lan; Saito, Daisuke Roland; Stergiades, Ioanna; Van Dyke, Priscilla M.; Dalziel, Sean; Preza, Leticia Maria; US2007/219278; (2007); A1;,
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