Month: June 2021

Reference of 5299-60-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, molecular weight is 160.21, as common compound, the synthetic route is as follows.

The PCC (16.20g, 75 . 50mmol) dissolved in dichloromethane (140 ml) in, lowering the temperature to 0 C, dropping 6 – hydroxy hexanoic acid ester (10.30g, 64 . 30mmol) of dichloromethane (20 ml) solution. Heating the reaction to room temperature, stirring the reaction 2 hours, adding ethyl acetate (100 ml), filtered, the filtrate is concentrated. The residue by silica gel column chromatography (petroleum ether/ethyl acetate (v/v)=10/1) to obtain the title compound as white solid (9.28g, 45.0%).

Statistics shows that 5299-60-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 6-hydroxyhexanoate.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Gao Jinheng; Zhang Yingjun; (37 pag.)CN106279153; (2017); A;,
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Application of 42142-52-9 ,Some common heterocyclic compound, 42142-52-9, molecular formula is C10H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

250 milliliters of N,N-dimethylacetamide was taken into round bottom flask to which 115.3 grams of potassium tertiary butoxide, 100 grams of N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine and 100 grams of 2-fluorotoulene were added,followed by heating to 120 to 130C for about 12 to 14 hours. Solvent was distilled from the above reaction mass under vacuum below 118 to 122C, followed by the addition of 500 milliliters of methanol and 300 milliliters of a 45-50 percent by weight sodium hydroxide solution. The reaction mass was transferred into an autoclave and then heated to a temperature of 105 to 110C for about 6 to 7 hours. The solvent was totally distilled off under vacuum at a temperature below 80C, then 1 liter of demineralised water and 1 liter of toluene were added, followed by cooling to 0 to 5C and adjusting the pH to a value between 8 and 9 with dilute hydrochloric acid. The above reaction mass was stirred for about 15 to 30 minutes to separate the organic and aqueous layers and the aqueous layer was extracted with 400 milliliters of toluene followed by stirring for about 5 to 10 minutes. Organic and aqueous layers were separated and the combined organic layers were washed with 400 milliliters of dimineralised water. The organic layer was taken into a round bottom flask followed by complete distillation under vacuum below 80C and then cooled to 25 to 35C. 1.3 liters of acetone and 64.2 grams of oxalic acid were added to the round bottom flask followed by stirring for about 45 to 60 minutes. The solid mass that was obtained was filtered and washed with 520 milliliters of acetone, and then slurried in 700 milliliters of acetonitrile in a round bottom flask and stirred for about 30 to 45 minutes. The solid mass was isolated by filtration and washed with 200 milliliters of acetonitrile, followed by drying at 50 to 60C for 4 to 5 hours under vacuum to afford atomoxetine oxalate.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 42142-52-9, 3-(Methylamino)-1-phenylpropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/9884; (2006); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H14O4

Polyethylene glycol (9 g, 60 mmol) was dissolved in 70 mL of toluene,Then, 10.2 mL of 48% HBr aqueous solution was added, heated to reflux,With sodium bicarbonate to absorb the release of gas,The reaction temperature was controlled at 115 C and the reaction was stirred for 3 days.After cooling, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate and then solvent was removed. 30 mL of water was added and extracted with CH 2 Cl 2 (3 × 60 mL).The combined organic phases were dried over anhydrous sodium sulfate, and the organic solvent was stripped to give 5.2 g of compound 15 in 41% yield.

With the rapid development of chemical substances, we look forward to future research findings about 112-27-6.

Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Yang Qinglai; Tan Lianjiang; Li Xinhui; Shao Zhifeng; Gong Bing; Li Xiaowei; Liu Yazhi; Zhang Zhen; (35 pag.)CN104725453; (2017); B;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol. A new synthetic method of this compound is introduced below., Safety of 4-(4-Methoxyphenyl)-1-butanol

To a stirred solution of 4-(4-methoxyphenyl)butanoi (1 equiv.) in dry dichloromethane at – 100C under an argon atmosphere was added boron tribromide (2.7 equiv., using a 1 M solution of boron tribromide in CH2Cl2)- Stirring was continued at that temperature until completion of the reaction (4 hours). Unreacted boron tribromide was destroyed by addition of aqueous saturated NaHCO3 solution at 00C. The resulting mixture diluted with CH2Cl2 and water, the organic phase was separated, washed with brine, dried (MgSO4) and evaporated. Purification by flash column chromatography on silica gel (30percent diethyl ether-hexane) afforded the title compound in 42percent yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52244-70-9, 4-(4-Methoxyphenyl)-1-butanol.

Reference:
Patent; UNIVERSITY OF CONNECTICUT; WO2008/13963; (2008); A2;,
Alcohol – Wikipedia,
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Synthetic Route of 186020-66-6 , The common heterocyclic compound, 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, molecular formula is C13H26O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of tert-butyl 3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy) propanoate (30.20 g, 108.5 mmol, 1.0 eq.) and TsCl (41.37 g, 217.0 mmol, 2.0 eq.) in anhydrous DCM (220 mL) at 0 C was added TEA (30.0 mL, 217.0 mmol, 2.0 eq.). The mixture was stirred at room temperature overnight, and then washed with water (3 × 300 mL) and brine (300 mL), dried over anhydrous Na2SO4, filtered, concentrated and purified by SiO2 column chromatography (3:1 hexanes/ EtOAc) to give a colorless oil (39.4 g, 84.0% yield). MS ESI m/z calcd for C20H33O8S [M + H]+ 433.1818, found 433.2838.

The synthetic route of 186020-66-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUZHOU M-CONJ BIOTECH CO., LTD.; HANGZHOU DAC BIOTECH CO, LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; GAI, Shun; ZHAO, Linyao; YE, Hangbo; GUO, Huihui; TONG, qianqian; CAO, Minjun; JIA, Junxiang; YANG, Chengyu; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; LIN, Chen; GUO, Zhixiang; YE, Zhicang; (246 pag.)WO2016/59622; (2016); A2;,
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Synthetic Route of 17701-61-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-hydroxybenzaldehyde (2.7 g), benzyl hydroxypivalate (4.7 g) and triphenylphosphine (6.4 g) in tetrahydrofuran (22 mL) was added diethyl azodicarboxylate (40% toluene solution, 11 mL), and the mixture was stirred at room temperature for 2 days. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate = 6/1 – 4/1) to give the title compound (0.97 g).1H-NMR (CDCl3) delta ppm: 1.36 (6H, s), 4.07 (2H, s), 5.15 (2H, s), 6.9-7.0 (2H, m), 7 . 2-7 . 35 (5H, m), 7.75-7.85 (2H, m), 9.89 (1H, s)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17701-61-0, Benzyl 3-hydroxy-2,2-dimethylpropanoate.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1544208; (2005); A1;,
Alcohol – Wikipedia,
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Related Products of 33420-52-9, Adding some certain compound to certain chemical reactions, such as: 33420-52-9, name is 2,2-Difluoropropan-1-ol,molecular formula is C3H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33420-52-9.

To a solution of 2,2-difluoropropan-1-ol (5.00 g, 52.0 mmol) and triethylamine (9.40mL, 67.6 mmol) in DCM (75 mL) was added trifluoromethanesulfonic anhydride (10.5 mL, 62.4mmol) dropwise at -20 C, and then allowed to move to 0 C, stirred overnight. The mixture wasdiluted with DCM (75 mL), then poured into ice water (100 mL). The separated organic layerwas washed with 20% Na2C03 aqueous solution (50 mL) and brine (50 mL) successively, anddried over Na2S04, filtered and concentrated in vacuo to afford the target compound as black oil(11.41 g, yield 96.1%).1HNMR (400 MHz, DMSO-d6) 8 (ppm): 5.08 (t, J= 13.5 Hz, 2H), 1.72 (t, J= 19.3 Hz, 3H);19F NMR (376 MHz, DMSO-d6) 8 (ppm): -74.6, -99.7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33420-52-9, 2,2-Difluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1475-13-4, name is 1-(2,4-Dichlorophenyl)ethanol. A new synthetic method of this compound is introduced below., Computed Properties of C8H8Cl2O

General procedure: A mixture of 2 mmol of substrate, and 4 mL ethylene glycol was stirred for 5 min, and then 2.4 mmol of DBDMH or 4.6 mmol of NBS was added by 5 times in one hour, and the mixture was stirred 24 h at room temperature. Afterward, the mixture was extracted with ether (10 mL × 3). The combined organic layer was washed twice by water (20 mL), and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure, and the residual was treated with alumina chromatography (Petroleum ether/AcOEt=20/1,V/V) to generate the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1475-13-4, 1-(2,4-Dichlorophenyl)ethanol.

Reference:
Article; Han, Bingbing; Zheng, Zubiao; Wu, Fang; Wang, Aidong; Synthetic Communications; vol. 47; 24; (2017); p. 2387 – 2394;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5333-42-6, name is 2-octyldodecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C20H42O

Into a 250 ml glass reactor fitted with an Argon purge was placed the nonanoic acid (20.5 grams, 0.2 moles), 2-octyl-1-dodecanol (29.9 grams, 0.1 moles) and p-toluene sulfonic acid monohydrate (19 grams, 0.1 moles). The mixture above was purged with Argon at room temperature for one hour. The mixture was then heated to 100 C. under Argon purge for 18 hours. The mixture was then cooled to room temperature. The residue was then dissolved into 100 ml with ethyl acetate and placed into a separatory funnel. The ethyl acetate solution was extracted once with 100 ml of distilled water. The ethyl acetate layer was washed with 250 ml 10 wt % NaHCO3 aqueous solution followed by 250 ml saturated NaCl aqueous solution. The ethyl acetate solution was dried over MgSO4 and then filtered. The ethyl acetate was removed on the rotary evaporator from the solution. The residue from the rotary evaporator was placed on a Kugelrohr vacuum distillation apparatus where the ester was distilled. 1H NMR (CDCl3): delta4.01 (d, 2H, O-CH2-), 2.31 (d, 2H, O=C-CH2-), 1.63-1.33 (m, 45H, -CH2-), 0.88 (t, 9H, CH3). IR (cm-1): 2955, 2954, 2854, 1738, 1466, 1378, 1251, 1251, 1165, 1107, 722.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5333-42-6, 2-octyldodecan-1-ol.

Reference:
Patent; ExxonMobil Chemical Patents Inc.; Patil, Abhimanyu O.; Lewis, Kyle G.; Bodige, Satish; Zushma, Stephen; US2019/62663; (2019); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 2043-47-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. A new synthetic method of this compound is introduced below.

Example 6In a 100-ml, three-necked glass reactor were placed 50 ml of methylene chloride, 10 g (38 mmol) of 3,3,4,4,5,5,6,6,6-nonafluorohexanol, 5 g (69 mmol) of acrylic acid, 7 g (40 mmol) of benzenesulfonic acid chloride and 0.1 g of a polymerization inhibitor, Sumilizer GM. While the reactor-inside temperature was kept at 40 C. or lower, 14 g (139 mmol) of N-methylmorpholine was added dropwise. At this point, the conversion was 95% and the selectivity was 99%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2043-47-2, its application will become more common.

Reference:
Patent; TOKUYAMA CORPORATION; DAIKIN INDUSTRIES, LTD.; US2009/23948; (2009); A1;,
Alcohol – Wikipedia,
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