Month: June 2021

Reference of 223251-16-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 223251-16-9 as follows.

This material is prepared from the amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]azapine by treatment with thionyl chloride in THF at 0C. Resulting solid is used without further purification.1H-NMR (CDCl3) delta 1.7 (m, 2H), 1.9 (m, 4H), 2.2 (m, 2H), 3.1 (m, 2H), 3.4 (7, 2H), 3.6 (t.2H), 6.9 (d, 2H), 7.3 (d, 2H), 12.5 (1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,223251-16-9, its application will become more common.

Reference:
Patent; Wyeth; EP1159267; (2004); B1;,
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Application of 17849-38-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 17849-38-6 as follows.

4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 2- chlorobenzyl alcohol (171mg, 1.2 mmol) and water (1ml) were successively added 25ml Schlenk reaction flask.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.A large amount of precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 92%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17849-38-6, its application will become more common.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
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Reference of 14320-38-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, molecular weight is 84.12, as common compound, the synthetic route is as follows.

Cyclopent-3-en-l-ol (10 g, 118.9 mmol) was dissolved in DMF (100 mL) at 0 C, then lH-imidazole (17.29 mL, 261.5 mmol) was added followed by tert- butyl(chloro)dimethylsilane (21.5 g, 142.7 mmol) and warmed up to r.t.. The mixture was stirred at r.t. for 14 h, diluted with EtOAc (300 mL) and washed with 5 % LiCl (2x 100 mL), brine (50 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by flash column chromatography (Si02, 0-10% EtOAc in hexanes) to afford 17.2 g (73 %) of the title product as a colourless clear liquid. 1H NMR (250 MHz, CDC13) delta ppm 5.66 (s, 2H), 4.53 (tt, J 7.0, 3.6 Hz, 1H), 2.57 (dd, J 15.2, 6.8 Hz, 2H), 2.27 (dd, J 15.3, 3.6 Hz, 2H), 0.89 (s, 9H), 0.06 (s, 6H).

The chemical industry reduces the impact on the environment during synthesis 14320-38-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki, Peter; BRACE, Gareth, Neil; BROWN, Julien, Alistair; CALMIANO, Mark, Daniel; CHOVATIA, Praful, Tulshi; DELIGNY, Michael; GALLIMORE, Ellen, Olivia; HEER, Jag, Paul; JACKSON, Victoria, Elizabeth; KROEPLIEN, Boris; MAC COSS, Malcolm; QUINCEY, Joanna, Rachel; SABNIS, Yogesh, Anil; SWINNEN, Dominique, Louis, Leon; ZHU, Zhaoning; WO2015/86526; (2015); A1;,
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Application of 30951-66-7, Adding some certain compound to certain chemical reactions, such as: 30951-66-7, name is 2-(3-Bromophenyl)propan-2-ol,molecular formula is C9H11BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 30951-66-7.

11.1 [1-(3-Bromophenyl)-1-(methyl)ethyl]oxytrimethylsilane 3.4 g of the compound prepared according to 7.1 in 80 ml of dichloromethane, at 0 C., are placed in a round-bottomed flask. 5.6 ml of triethylamine and 4.5 ml of trimethylsilane chloride are added. The mixture is stirred for one hour at 0 C. and 20 h at ambient temperature. 50 ml of water are added and the mixture is extracted with 30 ml of dichloromethane. The organic phase is washed with 20 ml of a saturated solution of sodium chloride, dried over magnesium sulphate and then concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a heptane/ethyl acetate mixture. 2.5 g of compound are obtained. 1H NMR (CDCl3, delta in ppm): 0 (s, 9H); 1.45 (s, 6H); 7.15 to 7.25 (m, 3H); 7.45 (m, 1H).

According to the analysis of related databases, 30951-66-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI-AVENTIS; US2011/65727; (2011); A1;,
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Related Products of 145691-59-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 145691-59-4, name is (3,5-Dibromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

1,3-Dibromo-5-ethoxymethyl-benzene A solution of 3,5-dibromobenzyl alcohol (2.0 h, 8 mmol) in tetrahydrofuran (80 mL) was cooled to 5° C. and treated with sodium hydride (dispersion in oil 55percent; 316 mg, 8 mmol). The mixture was left to warm to room temperature and stirred for 15 min. Ethyliodide (2.35 g, 15 mmol) was added and the mixture stirred for 5 h. For the working-up, the reaction mixture was evaporated, then extracted with a mixture of ethyl acetate and saturated sodium hydrogencarbonate solution. After the aqueous layer was re-extracted twice with ethyl acetate, the organic layers were combined, dried over sodium sulfate, and evaporated under reduced pressure. There were obtained 1.15 g of the title compound (yield: 52percent) as a yellow oil in sufficient purity to be engaged in the next step without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 145691-59-4, (3,5-Dibromophenyl)methanol.

Reference:
Patent; Andreini, Matteo; Gabellieri, Emanuele; Guba, Wolfgang; Marconi, Guido; Narquizian, Robert; Power, Eoin; Travagli, Massimiliano; Woltering, Thomas; Wostl, Wolfgang; US2009/209529; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6240-11-5, 1-Adamantaneethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6240-11-5, blongs to alcohols-buliding-blocks compound. Formula: C12H20O

(a) 2-[2-(1-Adamantyl)ethyloxy]ethylamine The desired intermediate was obtained, according to the procedure of Example 11, starting from 1-(2-hydroxyethyl)adamantane. Yield: 46%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6240-11-5, its application will become more common.

Reference:
Patent; Ausonia Farmaceutici s.r.l.; US4634701; (1987); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Example 4 (Table 1, entry 2, and Scheme 6): Preparation 2-[2-(aminocarbonyl)(2- chloroethyl)-4,6-dinitroanilino] ethyl methanesulfonate (13a); A solution of 2-chloro-3,5- dinitrobenzamide (11) (250 mg, 1.15 mmol) in THF (20 mL) was cooled to below 5 0C, and aziridineethanol (240 mg, 2.76 mmol) was added over 10 min to the stirred mixture, which was then kept at 20 0C overnight. Water (50 mL) was added, followed by EtOAc (50 mL). The mixture was separated and aqueous phase was extracted with EtOAc (2×60 mL). The combined organic fractions were washed with brine, dried and concentrated under reduced pressure, chromatography on silica gel and elution with EtOAc/petroleum ether (1:1), to give 2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitrobenzamide (12a) (350 mg, 92%) as a yellow solid: mp (EtOAc/petroleum ether) 96-100 C; 1H NMR [(CD3)2SO] delta 8.69 (d, / = 2.8 Hz, 1 H), 8.43 (s, 1 H, CONH), 8.35 (dj = 2.8 Hz, 1 H), 8.10 (s, 1 H), 5.15 (tj = 5.6 Hz, 1 H), 3.77 (m, 2 H), 3.54 (m, 4 H), 3.14 (m, 2 H); 13C NMR delta 167.6, 146.7, 143.8, 139.7, 134.1, 128.2, 123.1, 57.8, 54.3, 53.6, 41.4; Anal. Calcd. for C11H13ClN4O6: C, 39.7; H, 3.9, N, 16.8. Found: C, 38.4; H, 4.4; N, 15.7%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072-52-2, 2-(Aziridin-1-yl)ethanol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Related Products of 22436-06-2 , The common heterocyclic compound, 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Acetyl chloride (1.816 g, 23.14 mmol) was added slowly to a solution of (±)-4a (1.728 g, 11.50 mmol) and dry pyridine (2.757 g,34.85 mmol) in dry CH2Cl2 (30 mL) at 0 C. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with water (30 mL) at 0 C. The mixture was extracted with Et2O (50 mL). The organic layer was washed with brine (30 mL), dried over anhydrous Na2SO4 and filtered. After removal ofthe solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc 5/1) to afford (±)-5a (2.079 g, 94%) as a colorless oil. 1H NMR data were identical to those reported in the literature [40].

The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kato, Daiki; Kawasaki, Masashi; Morita, Yuko; Okada, Takuya; Tanaka, Yasuo; Toyooka, Naoki; Tetrahedron; (2020);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 440-60-8, name is (Perfluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (Perfluorophenyl)methanol

Example 11 In a 30 ml two-necked flask were added 0.004 g of LeOH.H2O, 0.40 g of methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.8 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropanecarboxylate was 84% based on the starting ester.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 440-60-8, (Perfluorophenyl)methanol.

Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
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Related Products of 50919-06-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50919-06-7, name is 2-(2-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 5.1.57.3. Step 3. To a solution of 2-(3-fluorophenyl)ethanol(25.26 g, 180 mmol) in pyridine (180 mL) was added TsCl(36.49 g, 186 mmol) at 0 C with silica gel blue tube. After stirringat rt for 4 h, the reaction was quenched by the addition of 2 N HCl (750 mL) at 0 C. This mixture was extracted with EtOAc (300 mL).The separable organic layer was washed with 2 N HCl (250 mL),H2O (200 mL), brine (100 mL), and dried over MgSO4, filtered, concentratedunder reduced pressure. The residue was purified by columnchromatography (SiO2, n-hexane/EtOAc = 10/1-5/1) to obtain2-(3-fluorophenyl)ethyl 4-methylbenzenesulfonate (38.54 g, 73%)as a colorless oil.

According to the analysis of related databases, 50919-06-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Imaeda, Toshihiro; Ono, Koji; Nakai, Kazuo; Hori, Yasunobu; Matsukawa, Jun; Takagi, Terufumi; Fujioka, Yasushi; Tarui, Naoki; Kondo, Mitsuyo; Imanishi, Akio; Inatomi, Nobuhiro; Kajino, Masahiro; Itoh, Fumio; Nishida, Haruyuki; Bioorganic and Medicinal Chemistry; vol. 25; 14; (2017); p. 3719 – 3735;,
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