Month: June 2021

Related Products of 149965-40-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol, molecular formula is C7H6BrClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

60 g PCC and 60 g silica gel powder were added to a round bottom flask; after mixing, 500 mL dichloromethane was added; cooled to 0 C., and 45 g of compound 1-1 in dichloromethane (300 mL) was added dropwise with stirring; maintaining 0 C.The reaction was monitored by TLC; after the reaction was completed, the reaction solution was spin-dried; 38 g of Compound 1-2 was isolated by column separation, and the yield in two steps was 90%.

According to the analysis of related databases, 149965-40-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangzhou Medical University; Hu Wenhui; Yu Xiyong; Zhao Xin; Wu Bo; (25 pag.)CN107556276; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 143726-85-6, tert-Butyl 4-(hydroxymethyl)benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 143726-85-6, blongs to alcohols-buliding-blocks compound. Recommanded Product: 143726-85-6

alpha-[4-Chlorobenzenesulfonylamino]-3,5- difluorobenzeneacetamide (300 mg, 0.83 mmol) was dissolved in dry THF (2.5 mL) and the resulting solution was cooled to 0 0C with stirring under a nitrogen atmosphere. Diisopropylazodicarboxylate (420 mg, 409 muL, 2.08 mmol) was added and the reaction mixture was stirred for 15 min. t-Butyl 4-hydroxymethylbenzoate (433 mg, 2.08 mmol) was dissolved in dry THF (2.5 mL) and the resulting solution was cooled to 00C with stirring under a nitrogen atmosphere. Triphenylphosphine (545 mg, 2.08 mmol) was added and the reaction mixture was stirred for 15 min. The solution containing the alcohol was added to the other solution in one portion. The reaction mixture was warmed to ambient temperature over 18h; then it was diluted with EtOAc (50 mL). The organic solution was washed with water (15 mL) four times and with brine (20 mL) twice. Drying over MgSO4, filtration and concentration of the filtrate in vacuo gave crude product. Column chromatography was performed twice (EtOAc:hexane:: 1:4, then 1 :3 (twice)). The crude product was then triturated six times with a mixture of hexane-ether-MeOH (8: 1 : 1). Drying in vacuo afforded the title product (white solid, 207 mg, 45% yield): 1H NMR (MeOH- d4, 300 MHz): 7.81 (d, 2H, J = 8), 7.65 (d, 2H, J = 8), 7.55 (d, 2H, J = 8), 7.10 (d, 2H, J = 8), 6.85 (d, 2H, J = 8), 6.76 (t, IH, J = 8), 5.82 (s, IH), 4.83 (m, 4H), 1.57(s, 9H); HRMS (ES+): Calcd for C26H29ClF2N3O5S (M+ + NH4): 568.1485, Found: 568.1475.

The synthetic route of 143726-85-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/137657; (2009); A1;,
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Reference of 4170-90-5 ,Some common heterocyclic compound, 4170-90-5, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a typical experiment, alcohol (10 mmol), aqueous NH3*H2O (30 mmol), FeCl4-IL-SiO2 (0.5 g), and CH3CN (10 mL) were added to a round-bottomed flask. Then, aqueous 30 % H2O2 (21 mmol) was gradually added into the reactor at room temperature. The obtained mixture was stirred at 30 C for appropriate time (Table 4). The reaction was monitored by TLC and GC. After completion of the reaction, the catalyst was recovered by filtration. Evaporation of the solvent under reduced pressure gave the crude product. Further purification was achieved by flash column chromatography on a silica gel (petroleum ether/ethyl acetate, 5:1) to give the desired product. Fresh substrates were then recharged to the recovered catalyst and then recycled under identical reaction conditions.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4170-90-5, Mesitylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hu, Yu-Lin; Wang, Bing Tong; Fang, Dong; Journal of the Iranian Chemical Society; vol. 14; 1; (2017); p. 233 – 243;,
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Related Products of 111-32-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-32-0, name is 4-Methoxybutan-1-ol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-MethoxybutanalTo a solution of 4-methoxybutan-1-ol (3 g, 28.8 mmol) in DCM (30 mL) was added PCC (9.31 g, 43.2 mmol) at 0 C.The reaction was stirred at RT for 1 h. The reaction mixture was filtered through celite, and washed with DCM (2X). The filtrate was concentrated to afford 4-methoxybutanal (1.5 g, 14.69 mmol, 51.0 % yield). H NMR (400 MHz, DMSO-d6) delta ppm 9.65 (s, 1 H), 4.00 (m, 2H), 3.30 (bs, 3H), 2.5 (m, 2H), 1.6 (m, 2H)

According to the analysis of related databases, 111-32-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; BOEHM, Jeffrey Charles; DAVIES, Thomas Glanmor; WOOLFORD, Alison Jo-anne; GRIFFITHS-JONES, Charlotte Mary; WILLEMS, Hendrika Maria Gerarda; NORTON, David; SAXTY, Gordon; HEIGHTMAN, Thomas Daniel; LI, Tindy; KERNS, Jeffrey K.; DAVIS, Roderick S.; YAN, Hongxing; WO2015/92713; (2015); A1;,
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Related Products of 56239-26-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56239-26-0, name is cis-4-Aminocyclohexanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

Potassium carbonate (78 g, 565 mmol) was added to ethyl 2,4-dichloropyrimidine-5- carboxylate (50.0 g, 226 mmol) and cis-4-aminocyclohexanol hydrochloride (34.3 g, 226 mmol) in acetonitrile (700 mL) at rt under air. The reaction mixture was stirred at rt for 16 h. The mixture was filtered through a Celite pad. The filtrate was concentrated under reduced pressure. The precipitate was collected by filtration, washed with MeCN (100 mL) and dried under vacuum to afford the title compound (41.0 g, 61percent) as a white solid; 1H NMR (400 MHz, DMSO) 1.32 (3H, t), 1.42 – 1.58 (2H, m), 1.60 – 1.75 (6H, m), 3.66 (1H, d), 4.06 (1H, dd), 4.33 (2H, q), 4.57 (1H, d), 8.46 (1H, d), 8.63 (1H, s); m/z MH+ 300.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56239-26-0, cis-4-Aminocyclohexanol hydrochloride.

Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; TING, Attilla, Kuan, Tsuei; (103 pag.)WO2018/114999; (2018); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1475-13-4, name is 1-(2,4-Dichlorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C8H8Cl2O

General procedure: The above secondary alcohol was dissolved in acetonitrile (30mL). Molecular sieve (1.5g), silica gel (1.5g) and activated MnO2 (3.5g, 40mmol) were added, and the mixture was stirred at 70C for 8h. upon completion of the oxidation, the resulting suspension was filtered through diatomite, and the filtrate was concentrated by rotary evaporation. Purification of the residue by column chromatography (petroleum ethrt/EtOAc, 15:1) afforded ketone 13.

With the rapid development of chemical substances, we look forward to future research findings about 1475-13-4.

Reference:
Article; Bi, Fangchao; Song, Di; Zhang, Nan; Liu, Zhiyang; Gu, Xinjie; Hu, Chaoyu; Cai, Xiaokang; Venter, Henrietta; Ma, Shutao; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 90 – 103;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate. A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 2-hydroxy-3-phenylpropanoate

General procedure: An aqueous CH3CN solution (CH3CN54 ml, H2O 6 ml) of N-Boc Val-OMe1a (0.6 mmol, 10 mM), phenanthrene(0.6 mmol, 10 mM), 1,4-dicyanobenzene (0.6 mmol, 10 mM) and NaOH (3 mmol, 50 mM)in three Pyrex vessels (18 mm x 180 mm) was purged with argon for 10 min andadded by acrylonitrile 2a (0.6 mmol,10 mM) under argon atmosphere. The mixture was heated by water bath at 40 for 2h and irradiated with a 100-W high-pressure mercury lamp for 3 h at roomtemperature. Then the mixture was evaporated, and the resulting residue wasdissolved in EtOAc and washed with water, dried over Na2SO4,and concentrated under reduced pressure. The product was purified by silica gelcolumn chromatography using hexane and EtOAc as eluents to give adduct 3a

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13674-16-3, Methyl 2-hydroxy-3-phenylpropanoate.

Reference:
Article; Saito, Hikaru; Kanetake, Takayuki; Osaka, Kazuyuki; Maeda, Kousuke; Morita, Toshio; Yoshimi, Yasuharu; Tetrahedron Letters; vol. 56; 13; (2015); p. 1645 – 1648;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4461-39-6, name is N-(2-Hydroxyethyl)-1,3-propanediamine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H14N2O

Lactone 14 (84 mg, 0.26 mmol) was dissolved in CHCl3 (15 mL) with stirring and a solution of 3-(2-hydroxyethyl)propylamine (20, 35 mg, 0.30 mmol) in CHCl3 (1 mL) was added. The mixture was heated at reflux with stirring under an argon atmosphere for 22 h and concentrated in vacuo until ?1 mL of solvent remained. Hexanes (1 mL) were added and the suspension was filtered and dried under high vacuum to provide 30 (93 mg, 84%) as a purple solid: mp 198 C. 1H NMR (500 MHz, DMSO-d6) delta 8.38 (d, J = 8.7 Hz, 1H), 8.02 (d, J = 2.4 Hz, 1H), 7.76 (dd, J = 8.7, 2.4 Hz, 1H), 7.63 (s, 1H), 7.10 (s, 1H), 6.18 (s, 2H), 4.59-4.27 (m, 3H), 3.44 (t, J = 5.7 Hz, 2H), 2.67 (t, J = 6.4 Hz, 2H), 2.58 (t, J = 5.8 Hz, 2H), 1.92-1.71 (m, 2H); ESIMS m/z (rel intensity) 427/429 (MH+, 100/31); HRESIMS calcd for C22H20ClN2O5 427.1061 (MH+), found 427.1067; HPLC purity, 98.60% (0.1% TFA in MeOH, 100%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4461-39-6, N-(2-Hydroxyethyl)-1,3-propanediamine.

Reference:
Article; Beck, Daniel E.; Lv, Wei; Abdelmalak, Monica; Plescia, Caroline B.; Agama, Keli; Marchand, Christophe; Pommier, Yves; Cushman, Mark; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1469 – 1479;,
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Synthetic Route of 5259-98-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, molecular weight is 122.59, as common compound, the synthetic route is as follows.

General procedure: The thiophenylmannoside 1 (440mg, 1.00mmol, 1.0equiv) and the corresponding alcohol (1.05equiv) in CH2Cl2 (5mL) were stirred at 25 °C in the presence of 4 A MS (500mg) for 30 min. After cooling to ?2°C with an ice/NaCl bath N-iodosuccinimide (270mg, 1.2mmol, 1.2equiv) and trifluoromethanesulfonic acid (30.0mg, 17.7mL, 200mmol, 0.2equiv) were slowly added and stirring continued at this temperature for 1h. The reaction mixture was allowed to warm to 25 °C and then acetic anhydride (0.2-0.3mL, 2.0-3.0equiv) added. Work-up was analogous to GP1 and column chromatography was performed with a gradient 3:1?1:1 petrol/EtOAc to yield the mono, di and trisaccharides as colourless materials.

The chemical industry reduces the impact on the environment during synthesis 5259-98-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Schuster, Heiko J.; Vijayakrishnan, Balakumar; Davis, Benjamin G.; Carbohydrate Research; vol. 403; (2015); p. 135 – 141;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, molecular weight is 134.1736, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: TMSOTf (336 mg, 1.51 mmol) is added to a solution of the alcohol (0.755 mmol) in the respective nitrile (3 mL) and the mixture is stirred at rt for 65 h. H2O (25 mL) and brine (25 mL) are added, and the mixture is extracted with EtOAc (3 × 30 mL). The combined organic layers are dried (Na2SO4) and concentrated, and excess nitrile is distilled off at reduced pressure (90 C, 0.1 mbar). The crude product is purified by flash column chromatography (silica gel).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.

Reference:
Article; Pfaff, Dominik; Nemecek, Gregor; Podlech, Joachim; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1572 – 1577;,
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