Month: June 2021

Synthetic Route of 27646-80-6 ,Some common heterocyclic compound, 27646-80-6, molecular formula is C5H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-(4-Amino-3,5-dichlorophenyl)-4,5,5-trimethylmorpholin-2-ol (5)Lambda/-Methyl-2-amino-2-methyl-propan-1-ol (4) (4.6 g, 44.6 mmol) was added to a mixture of compound 2 (4.2 g, 14.8 mmol) in chloroform (17 ml). The mixture was stirred at room temperature for 2 h, and then water (9 ml) was added. The mixture was stirred for 1 h, and then the solid was filtered. The solid was triturated with water (1 L) to give the desired compound (1.2 g, 91 percent). 1H NMR (400 MHz, DMSO): 0.94 (6H, s), 3.18 (2H, d J=4.4 Hz), 3,93 (2H, s), 4.55 (1 H, m), 6.40 (2H, s), 7.84 (2H, s); 13C NMR (100 MHz1 DMSO): 24.21 , 48.87, 53.73, 68.52, 117.92, 124.57, 125.79, 128.62, 146.07, 195.30; LC-MS: 291 , 292, 293 (M + H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27646-80-6, its application will become more common.

Reference:
Patent; BIOCOPEA LIMITED; BANNISTER, Robin Mark; WO2010/103312; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57772-50-6, name is (2-Amino-3-methylphenyl)methanol, the common compound, a new synthetic route is introduced below. Product Details of 57772-50-6

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

The synthetic route of 57772-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
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Reference of 112-27-6, Adding some certain compound to certain chemical reactions, such as: 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol,molecular formula is C6H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112-27-6.

triethylene glycol single-ended p-toluenesulfonic acid ester synthesis: lmmol of triethylene glycol into the three-necked burningThe flask was filled with ImmoL pyridine, dissolved in 20 mL of dichloromethane and stirred in an ice bath at 0 C. ImmoL p-toluenesulfonyl chloride dissolved in dichloromethane was slowly added dropwise. After 3 hours, the reaction was washed with hydrochloric acid, and the organic layer was washed with water until the aqueous solution became neutral. Dried over anhydrous sodium sulfate, and separated by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gannan Normal University; Wu, Yongquan; Fan, Xiaolin; Ceng, Guanjie; Wu, Renmiao; Jiang, Tianyu; Li, Yibao; (11 pag.)CN105601675; (2016); A;,
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Electric Literature of 149104-89-2, Adding some certain compound to certain chemical reactions, such as: 149104-89-2, name is (4-Bromo-3-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149104-89-2.

9.10 g of (4-bromo-3-methylphenyl)methanol was dissolved in 91 ML of methylene chloride and cooled to 5°C, to which 19.7 ML of N-ethyldiisopropylamine and 6.9 ML of chloromethyl methyl ether were successively added dropwise at 5 to 10°C, and then this mixture was stirred for 2.5 hours at room temperature.. water was added to the reaction mixture and adjusted to PH 7 with 6M hydrochloric acid, and then the organic phase was separated therefrom.. After the resultant organic phase was washed with water and a saturated sodium chloride solution successively, the washed phase was dried over anhydrous sodium sulfate, and the solvent was distilled out under reduced pressure.. The resultant residue was purified by silica gel column chromatography [eluent; hexane:ethyl acetate=5:1] to yield 10.44 g of 1-bromo-4-[(methoxymethoxy)methyl]-2-methylbenzene as yellow oil. NMR(400MHz,CDCl3) delta value: 2.40(3H,s), 3.41(3H,s), 4.52(2H,s), 4.71(2H,s), 7.04(1H,dd,J=8.2,2.0Hz), 7.23(1H,d,J=1.6Hz), 7.50(1H,d,J=8.0Hz)

According to the analysis of related databases, 149104-89-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOYAMA CHEMICAL CO., LTD.; Hirono, Shuichi; Shiozawa, Shunichi; EP1445249; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.Safety of Cyclopentanemethanol

To a suspension of NaH (61 mg, 1,5 mmol) in THE (3 mL) at 0C cyclopentanemethanol (0.16 mL, 1 .5 mmol) was added. After 30 mm at 0C, 6-(6- hromopyridin-2-yl)-3 -((2-chlorophenyl)thio)-6-(thiophen-3-yl)piperidine-2,4-dione (150 mg, 0.30 mmol) was added and the reaction mixture was stirred for 1 8 hr at reflux. The reaction was stopped by the addition of water (10 mL) and HC1 1M (3 mL). The aqueous phase was extracted with ethyl acetate (3 x 10 mL) and the combined organic phases were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography (Si02, heptane/ethyl acetate: 8/2 to 7/3 to 1/1) to give 3-((2-chlorophenyl)thio)-6-(6- (cyclopentylmethoxy)pyridin-2-yl)-6-(thiophen-3 -yl)piperidine-2,4-dione in 62 % yield.?H NMR (400 MHz, MeOH-d4): 6 7.70 (t, J= 7.8 T-Iz, 1H), 7.43 (dd, J 5.0, 3.0 Hz, IH), 7.28 (br s, 1H), 7.22 (d, J= 7.9 HZ, 1H), 7.15-7.12 (m, 2H), 6.94 (t, J 7.8 Hz, IH), 6.77-6.73 (m, 2H), 5.98 (d, J= 8.0 Hz, 1H), 4.22 (m, 2H9, 3.91 (d, J 16.4 Hz, IH), 3.45 (d, .1= 16.4 Hz, IH), 3.45 (s, IH), 2.35-2.28 (m, lI-I), 1.82-1.73 (m, 2H), 1.64-1.51 (m, 4H), 1.38-1.30 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Patent; SPERMATECH AS; GOLDING, Louise; SIENG, Bora; LUNDVALL, Steffi; BØEN, Claudia Alejandra; HNIDA, Kathrin; (68 pag.)WO2018/211276; (2018); A1;,
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Synthetic Route of 37585-16-3, Adding some certain compound to certain chemical reactions, such as: 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37585-16-3.

General procedure: A 100-mL, three-necked flask equipped with a condenser was charged with Ph3P (2.20 g, 8.4 mmol), Et3N (0.85 g, 8.4 mmol),CBr4 (2.79 g, 8.4 mmol), and fluorine-containing carboxylic acid(2.8 mmol) in toluene (25.0 mL) at 0 C under a nitrogen atmosphereand the solution was then stirred for 10 min. 2-Aminobenzyl alcohol 1 (2.8 mmol) was added to the reaction mixture. Once theaddition was complete, the reaction mixture was heated to reflux for1-3 h. After cooling, the solvent was removed by rotary evaporator,the residue was then carefully washed three times with hexane-EtOAc (4:1), and the precipitate was removed by filtration. The filtratewas combined and concentrated by rotary evaporator. The residue was then purified by column chromatography (hexane-EtOAc,4:1) to give the product.

According to the analysis of related databases, 37585-16-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wang, Zeng-Xue; Zhang, Tai-Feng; Ma, Qing-Wen; Ni, Wei-Gui; Synthesis; vol. 46; 24; (2014); p. 3309 – 3314;,
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Synthetic Route of 33524-31-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

Benzyl bromides such as 2,5-Dimethoxybenzyl bromide and 2,3- dimethoxybenzyl bromide used in JV-alkylation reactions were optionally prepared from the corresponding benzyl alcohols by treating with carbon tetrabromide and triphenyl phosphine in dry dichloromethane (Scheme 4). The reaction was performed at ambient temperature for 30 minutes and the yield was 85 to 90%. EPO

At the same time, in my other blogs, there are other synthetic methods of this type of compound,33524-31-1, (2,5-Dimethoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; GE HEALTHCARE LIMITED; WO2007/36785; (2007); A2;,
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Adding a certain compound to certain chemical reactions, such as: 52273-77-5, 2-(3-Aminophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C8H11NO, blongs to alcohols-buliding-blocks compound. Formula: C8H11NO

The compounds were treated with p-chlorobenzoic acid (586 mg, 3.76 mmol), triethylamine (578 mL, 4.18 mmol) and HBTU(1580 mg, 4.18 mmol)Dissolved in methylene chloride,After stirring for 15 min, add3-aminophenylethanol2a (286 mg,2.09 mmol), 25 C for 12 hours,After completion of the reaction, the reaction solution was concentrated under reduced pressure,Add distilled water and extract with ethyl acetate(50 mL x 2), saturated brine,The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressureChromatography (petroleum ether: ethyl acetate = 3: 1) to give the intermediate 2b (282.5 mg, 0.099 mmol, white solidBody, yield 49.6%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52273-77-5, 2-(3-Aminophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hefei University of Technology; Liao Chenzhong; Zhang Xingxing; Xiao Xuan; Zhan Meimiao; Ma Jingwen; Zhu Mimi; Li Yinfeng; Guan Li; (32 pag.)CN107056630; (2017); A;,
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Related Products of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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Synthetic Route of 346-06-5, Adding some certain compound to certain chemical reactions, such as: 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol,molecular formula is C8H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 346-06-5.

EXAMPLE 1052-(trifluoromethyl)benzyl 7-bromo-3-oxo-2,3-dihydrospiro[indene-l ,4′-piperidine]-r- carboxylate To o-(trifluoromethyl)benzyl alcohol (35 mg, 0.20 mmol) in CH2Cl2 (4 mL) was added was a solution of carbonyl diimidazole (29 mg, 0.18 mmol) in CH2Cl2 (4 mL). The mixture was stirred at rt for 2 h. A 1-mL aliquot of the resulting solution (0.05 mmol) was added to a solution 7-bromospiro[indene-l,4′-piperidin]-3(2H)-one (14.5 mg, 0.05 mmol) in CH2Cl2 ( ImL). The mixture was stirred at rt for 16 h, concentrated, redissolved in MeCN (1 mL) and heated at 60 °C for 2 h. Prep HPLC afforded the title compound. LC-MS Method 1 tR = 2.06, min, m/z = 484, 482.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 346-06-5, (2-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; WO2009/108332; (2009); A1;,
Alcohol – Wikipedia,
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