New learning discoveries about 17100-64-0

The synthetic route of 17100-64-0 has been constantly updated, and we look forward to future research findings.

Reference of 17100-64-0 , The common heterocyclic compound, 17100-64-0, name is (4-Bromo-3-methoxyphenyl)methanol, molecular formula is C8H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate Example Int 10.27.011 -bromo-4-(ch loromethy l)-2-methoxybenzeneTo a stirred solution (4-bromo-3-methoxyphenyl)methanol (660 mg) in DCM (20 mL) was added N,N-Diisopropylethylamin (1 .59 mL) and methanesulfonyl chloride (0.36 mL) and the mixture was stirred at r.t. for 16 h. A half-saturated solution of sodium bicarbonate was added and the mixture was extracted with DCM. The organic phase was washed with saturated sodium chloride solution, dried (sodium sulfate) and the solvent was removed in vacuum. Silicagel chromatography gave 700 mg of the title compound.

The synthetic route of 17100-64-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; SCHULZE, Volker; KOSEMUND, Dirk; WENGNER, Antje, Margret; SIEMEISTER, Gerhard; STOeCKIGT, Detlef; LIENAU, Philip; SCHIROK, Hartmut; BRIEM, Hans; WO2012/143329; (2012); A1;,
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New learning discoveries about 558-42-9

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

To the mixture of 6-(3-Bromo-5-chloro-4-hydroxyphenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one (Reference example 87, 300 mg) was dissolved in ethanol-water (4 : 1, 10 mL) were added 1-chloro-2-methyl-2-propanol (0.388 mL) and potassium carbonate (522 mg). The reaction mixture was refluxed for 8 hours. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate, and filtrated, and the solvent was removed. The obtained crude product was purified by silica gel column chromatography (heptane : ethyl acetate = 67 : 33 to 33 : 67). The obtained solid was recrystallized from 2-propanol to afford the title compound as a white powder (107 mg).Melting point : 176.6-178.2°C

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; KATOH, Takahiro; IIDA, Masatoshi; TERAUCHI, Yuki; YAMAGUCHI, Kazuya; HIROSE, Toshiyuki; YOKOYAMA, Fumiharu; NISHIMORI, Hikaru; OBUCHI, Yutaka; NABESHIMA, Hiroshi; TAKAKI, Emiri; (250 pag.)WO2017/150654; (2017); A1;,
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New downstream synthetic route of 1475-13-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1475-13-4, its application will become more common.

Electric Literature of 1475-13-4 ,Some common heterocyclic compound, 1475-13-4, molecular formula is C8H8Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 4-chloro-2-trichloromethylquinazoline 1 (0.2 g, 0.71 mmol), DMAP (26 mg, 0.21 mmol, 0.3 equiv) and adequate alcohol derivative (0.85 mmol, 1.2 equiv) in toluene (3 mL) was introduced in miniaturized sealed reactor (5mL). The reaction mixture was irradiated in a monomode microwave oven, for 1 h at 130C. After removal of the toluene under reduced pressure, the residue was purified by silica gel column chromatography and recrystallized from appropriate solvent. 4.1.16 4-(1-(2,4-Dichlorophenyl)ethoxy)-2-(trichloromethyl)quinazoline (14) Yield 69%. Brown powder. Mp 123 C, (isopropanol). 1H NMR (200 MHz, CDCl3) delta = 8.31 (d, J = 8 Hz, 1H), 8.07 (d, J = 8 Hz, 1H), 7.96-7.87 (m, 1H), 7.69 (t, J = 7 Hz, 1H), 7.49-7.39 (m, 2H), 7.20 (dd, J = 2 Hz; 8 Hz, 1H), 6.78 (q, J = 7 Hz, 1H), 1.81 (d, J = 7 Hz, 3H) . 13C NMR (50 MHz, CDCl3) delta = 165.3, 159.2, 150.8, 135.3, 131.6, 130.8 129.4, 129.3, 129.0, 128.6, 123.4, 115.4, 96.9, 72.7, 21.0. LC-MS (ESI+) tR 6.02 min, m/z [M + H]+ 434.74/436.86/438.81. MW: 436.55 g/mol. Anal. Calcd for C17H11Cl5N2O: C, 46.77; H, 2.54; N, 6.42. Found: C, 46.41; H, 2.52; N, 6.51.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1475-13-4, its application will become more common.

Reference:
Article; Gellis, Armand; Primas, Nicolas; Hutter, Sebastien; Lanzada, Gilles; Remusat, Vincent; Verhaeghe, Pierre; Vanelle, Patrice; Azas, Nadine; European Journal of Medicinal Chemistry; vol. 119; (2016); p. 34 – 44;,
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Some tips on (2,6-Difluorophenyl)methanol

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19064-18-7, (2,6-Difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Application of 19064-18-7, Adding some certain compound to certain chemical reactions, such as: 19064-18-7, name is (2,6-Difluorophenyl)methanol,molecular formula is C7H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19064-18-7.

To a solution of 2.71 g of (2,6-difluorophenyl)methanol [CAS No.: 19064-18-7] (18.8 mmol, 1.3 eq.) in 120 ml of 1,2-dimethoxyethane were added 4.86 g of potassium tert-butoxide (43.3 mmol, 3.0 eq.) and the mixture was stirred at RT for 60 min. Subsequently, 2.60 g of 2-amino-3-chloro-5-methylpyrazine hydrochloride [CAS No.: 89182-14-9] (14.4 mmol, 1.0 eq.) were added and the mixture was stirred at 80 C. overnight. After cooling to room temperature, saturated aqueous sodium hydrogencarbonate solution was added and the aqueous phase was extracted three times with dichloromethane. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried with magnesium sulphate, filtered and concentrated. The residue was purified by means of Biotage Isolera (340 g silica gel cartridge, cyclohexane/ethyl acetate gradient, 10%->72% ethyl acetate). 1.77 g of the title compound were obtained (39% of theory; 85% purity). (0942) LC-MS (Method 2): Rt=0.94 min (0943) MS (ESpos): m/z=252 (M+H)+ (0944) 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=2.20 (s, 3H), 5.35 (s, 2H), 5.88 (s, 2H), 7.09-7.23 (m, 2H), 7.37 (s, 1H), 7.46-7.57 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19064-18-7, (2,6-Difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; Dietz, Lisa; LI, Volkhart Min-Jian; (85 pag.)US2016/176880; (2016); A1;,
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Analyzing the synthesis route of 637031-88-0

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 637031-88-0, 3,3-Difluorocyclobutanol.

Reference of 637031-88-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 637031-88-0, name is 3,3-Difluorocyclobutanol, molecular formula is C4H6F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 3,3-difluorocyclobutanol (25.19 mg, 0.23 mmol) and A-107 (33 mg, 0.12 mmol) in 1,4-dioxane (4 mL) was added i-BuOK (26.15 mg, 0.23 mmol) at 20 C. The mixture was stirred at 20 C for 2 hours. The mixture was quenched with sat. NH4C1 (10 mL) and extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (15 mL), dried over Na2S04, filtered and concentrated to give the crude product, which was purified by prep-TLC (silica gel, PE:EtOAc = 1: 1) and prep-HPLC (Phenomenex Gemini (250 mm x 50 mm,10 _); A = H20 (0.05% NH4OH) and B = CH3CN; 55-65% B over 8 minutes) to afford Compound 86 (1.72 mg, 0.05 mmol) as a solid. 1H NMR (400MHz, CDCI3) _ = 9.59 (d, 1H), 8.75 (d, 1H), 8.36 (s, 1H), 8.20 (dd, 1H), 6.94 (d, 1H), 5.30-5.18 (m, 1H), 3.24-3.11 (m, 2H), 2.85-2.71 (m, 2H). LCMS R, = 1.14 min using Method A, MS ESI calcd. for [M+H]+ 372.1, found 372.0.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 637031-88-0, 3,3-Difluorocyclobutanol.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
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A new synthetic route of 575-03-1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Related Products of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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Extracurricular laboratory: Synthetic route of 24131-31-5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 24131-31-5, (3,5-Bis(benzyloxy)phenyl)methanol.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24131-31-5, name is (3,5-Bis(benzyloxy)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Phosphorus tribromide was added to the CH2Cl2 solution (10 mL) of [3,5-bis(benzyloxy)phenyl]methanol (11, 0.008 mol) at 0 C for 2 h. Ice water was added to reaction solution, and extracted with diethyl ether. The crude product was evaporated and purified by silica-gel chromatography using petroleum/ethyl acetate 15:1 as an eluent to give bromide 12 (0.0028 mol, 35%). 1H-NMR (DMSO-d6, 300 MHz) delta: 7.11-7.43 (10H), 6.65 (2H, d, J = 2.1 Hz), 6.55 (1H, s), 5.03 (4H, br s), 4.35 (2H, s). HPLC analysis 96.9% (MeOH: H2O = 85: 15 (V/V), tR = 8.67 min).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 24131-31-5, (3,5-Bis(benzyloxy)phenyl)methanol.

Reference:
Article; Wan, Xiang; Wang, Xiao-Bing; Yang, Ming-Hua; Wang, Jun-Song; Kong, Ling-Yi; Bioorganic and Medicinal Chemistry; vol. 19; 17; (2011); p. 5085 – 5092;,
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Share a compound : 46190-45-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound,46190-45-8, Methyl 4-(2-hydroxyethyl)benzoate, and friends who are interested can also refer to it.

Reference of 46190-45-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 46190-45-8, name is Methyl 4-(2-hydroxyethyl)benzoate. A new synthetic method of this compound is introduced below.

Step 3 4-(2-Phenoxy-ethyl)-benzoic Acid Methyl Ester 72 4-(2-Hydroxyethyl)benzoic acid methyl ester 71 (1.622 g, 9.00 mmol), triphenyl phosphine (3.541 g, 13.50 mmol), and diethyl azodicarboxylate (2.13 ml, 13.50 mmol) were dissolved in 50 ml of tetrahydrofuran at room temperature and allowed to stir for 30 minutes. Phenol (0.847 g, 9.00 mmol) was added and the mixture was allowed to stir overnight. The mixture was diluted with water and extracted with diethyl ether. The extracts were dried over anhydrous sodium sulfate and concentrated en vacuo. The residue was purified by flash chromatography on silica eluted with 99:1 hexane/acetone to give 387 mg (16.8%) of 4-(2-phenoxy-ethyl)-benzoic acid methyl ester 72 as a clear oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,46190-45-8, Methyl 4-(2-hydroxyethyl)benzoate, and friends who are interested can also refer to it.

Reference:
Patent; Cournoyer, Richard Leo; Keitz, Paul Francis; Lowrie Jr., Lee Edwin; Muehldorf, Alexander Victor; O’Yang, Counde; Yasuda, Dennis Mitsugu; US2001/56100; (2001); A1;,
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Share a compound : 1074-61-9

The synthetic route of 1074-61-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1074-61-9 , The common heterocyclic compound, 1074-61-9, name is (4-Vinylphenyl)methanol, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step A 1-Bromomethyl-4-vinyl-benzene. Bromine (16.4 g, 103 mmol) was slowly added to a solution of triphenylphosphine (28.87 g, 110.1 mmol) in CH2Cl2 (260 mL) at 0 C. After 10 minutes, 4-vinylbenzyl alcohol (12.5 g, 93.3 mmol) was added and the reaction mixture was stirred at 0 C. for 2 h. The reaction mixture was washed with water (1*) followed by brine (1*). The organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The product was triturated with petroleum ether (3*), and the ethereal solution was concentrated in vacuo. The residue was purified by flash chromatography (hexanes) to afford 4-vinyl-benzyl bromide (6.23 g). 1H NMR (400 MHz, CDCl3) delta 7.32-7.45 (m, 4H), 6.72 (dd, 1H), 5.77 (d, 1H), 5.28 (d, 1H), 4.50 (s, 2H).

The synthetic route of 1074-61-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US6288120; (2001); B1;,
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Some tips on 2568-33-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 2568-33-4, 3-Methylbutane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 3-Methylbutane-1,3-diol, blongs to alcohols-buliding-blocks compound. Safety of 3-Methylbutane-1,3-diol

To a solution of ethyl (2E) -3- (2-{ [3-chloro-5- (trifluoromethyl)pyridin-2-yl]oxy}-4-hydroxyphenyl) acrylate (10.0 g) in tetrahydrofuran (300 ml) were added tributylphosphine (10.5 ml), 3-methylbutane-l, 3-diol (4.0 ml) and 1, 1′ – (azodicarbonyl) dipiperidine (9.7,6 g) , and the mixture was stirred overnight at 500C. Then, tributylphosphine (10.5 ml), 3-methylbutane-l, 3-diol (4.0 ml) and 1,1′- (azodicarbonyl) dipiperidine (9.76 g) were added, and the mixture was stirred at 500C for 1 hr. The reaction mixture was concentrated, the obtained solid was washed with diisopropyl ether, and the filtrate was concentrated. The obtained residue was subjected to basic silica gel column chromatography, and eluted with ethyl acetate-hexane (hexane alone to 45:55, v/v). The obtained residue was subjected to silica gel column chromatography, and eluted with ethyl acetate-hexane (hexane alone to 3:7, v/v) to give ethyl (2E) -3- [2-{ [3-chloro-5- (trifluoromethyl)pyridin-2-yl]oxy}-4- (3-hydroxy-3- methylbutoxy) phenyl] acrylate (Reference Example 264) (1.46. g, yield: 12-%) ,as a pale-yellow solid. Recrystallization from ethyl acetate-hexane gave white crystals as 0.5 hydrate, melting point 63.5-66.00C.Then, ethyl (2E) -3- [2-{ [3-chloro-5-(trifluoromethyl) pyridin-2-yl] oxy}-4- (3-hydroxy-l, 1- dimethylpropoxy) phenyl] acrylate (Reference Example 265) (0.71 g, yield: 6%) was obtained as an orange oil.1H-NMR (300 MHz, DMSO-ds)delta: 1.20 (3 H, t, J = 7,2 Hz), 1.32 (6 H, s), 1.87 (2 H, t, J = 7.5 Hz), 3.55 – 3.62 (2 H, m) , 4.12 (2 H, q, J = 7.2 Hz), 4.40 (1 H, t, J = 5.4 Hz), 6.57 (1 H, d, J = 16.2 Hz), 6.96 (1 H, s) , 6.94 – 6.99 (1 H, m) , 7.55 (1 H, d, J = 16.2 Hz), 8.50 – 8.50 (1 H, m) , 8.63 (1 H, d, J = 2.0 EPO Hz ) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
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