Electric Literature of 2867-59-6 ,Some common heterocyclic compound, 2867-59-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-(3-Fluorophenyl)-3-oxo-6-[4-(trifluorom acid (100 mg, 0.26 mmol) was dissolved in anhydrous DMF (2.0 ml_). (3RS)-3-Aminobutan-1 -ol (47.1 mg, 0.53 mmol), N-ethyl-N-isopropylpropan-2-amine (0.207 ml_, 1.19 mmol), and propane phosphonic acid anhydride (T3P, 231 muIota_, 50% in DMF, 397 muetaiotaomicronIota) were successively added. It was stirred at rt overnight. The crude reaction mixture was purified by RP-HPLC (column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: (water + 0.1 vol% formic acid (99%)) / acetonitrile, gradient) to yield 88.3 mg (74%) of the title compound. 1H-NMR (400MHz, DMSO-d6): delta [ppm] = 1 .19 (d, 3H), 1.60 – 1.74 (m, 2H), 3.45 – 3.51 (m, 2H), 4.09 – 4.21 (m, 1 H), 4.51 (t, 1 H), 7.36 – 7.43 (m, 1 H), 7.54 – 7.58 (m, 1 H), 7.59 – 7.66 (m, 2H), 7.88 (d, 2H), 8.20 (d, 2H), 8.70 (s, 1 H), 9.29 (d, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2867-59-6, 3-Aminobutan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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